Evidence map›Paper›PMID 30297396›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

iNOS promotes CD24

Ronghua Wang, Yawen Li, Allan Tsung, Hai Huang, Qiang Du, Muqing Yang, Meihong Deng, Si Xiong, Xiju Wang, Liyong Zhang and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.

  1. Pooled it
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  14. Regulation of Cancer Stem Cells in the Tumor Microenvironment.Cancer heterogeneity and plasticity · 2025
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Ronghua WangDepartment of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yawen LiDepartment of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Allan TsungDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Hai HuangDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Qiang DuDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Muqing YangDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Meihong DengDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Si XiongDepartment of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiju WangDepartment of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Liyong ZhangDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
David A GellerDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Bin ChengDepartment of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; b.cheng@tjh.tjmu.edu.cn billiartr@upmc.edu.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 b.cheng@tjh.tjmu.edu.cn billiartr@upmc.edu.ORCID 0000-0002-2949-0811
University of Pittsburgh · USTongji Hospital · CN

Funding

NITRIC OXIDE AND HEPATIC FUNCTION IN SEPSIS AND TRAUMAR01GM044100 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BILLIAR, TIMOTHY R · 1995 to 2017
$1.9M
NIGMS NIH HHS R01 GM044100
6 · The paper itself

Abstract

The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors, including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes cancer progression and requires Notch cleavage by ADAM (a disintegrin and metalloprotease) proteases. We hypothesized that iNOS/NO promotes Notch1 activation through TACE/ADAM17 activation in liver cancer stem cells (LCSCs), leading to a more aggressive cancer phenotype. Expression of the stem cell markers CD24 and CD133 in the tumors of patients with HCC was associated with greater iNOS expression and worse outcomes. The expression of iNOS in CD24

Indexed as

AC133 AntigenADAM17 ProteinBiomarkers, TumorCD24 AntigenCell Line, TumorFemaleHumansLiver NeoplasmsMaleMiddle AgedNeoplastic Stem CellsNitric Oxide Synthase Type IIPhenotypeReceptors, NotchSignal TransductionUp-RegulationAC133 AntigenADAM17 ProteinADAM17 protein, humanBiomarkers, TumorCD24 AntigenCD24 protein, humanNitric Oxide Synthase Type IINOS2 protein, humanPROM1 protein, humanReceptors, Notchcancer stem cellshepatocellular carcinomanitric oxideNotchTACE/ADAM17

Identifiers

PMID30297396
PMCPMC6205478
OpenAlexW2896304406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.