Evidence map›Paper›PMID 30297368›Full record

ArticleAntimicrobial agents and chemotherapy2018

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have

Luther A Bartelt, David T Bolick, Glynis L Kolling, Erin Stebbins, Christopher D Huston, Richard L Guerrant, Paul S Hoffman

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Evaluation of potential antiparasitic effect of ZnO nanoparticles on experimental cryptosporidiosis in immunosuppressed mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Systemic efficacy onParasitology · 2021
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luther A BarteltDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA luther_bartelt@med.unc.edu.
David T BolickDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Glynis L KollingDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Erin StebbinsDivision of Infectious Diseases, Department of Medicine, University of Vermont, Burlington, Vermont, USA.
Christopher D HustonDivision of Infectious Diseases, Department of Medicine, University of Vermont, Burlington, Vermont, USA.
Richard L GuerrantDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Paul S HoffmanDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USUniversity of Vermont · USUniversity of North Carolina at Chapel Hill · US

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Laurent Hébert-Dufresne · 2018 to 2026
$24.9M
VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2006 to 2011
$14.5M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
Cytokine signaling and IEC restitution in enteropathy: the Giardia paradigmK08AI108730 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARTELT, LUTHER A · 2014 to 2018
$938k
Role of glucocorticoid receptor-mediated mRNA decay in alcohol dependenceR21AA030807 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI CONTET, CANDICE · 2023 to 2024
$478k
PFOR inhibitor amixicile for treatment of drug resistant parasites and bacteriaR21AI111604 · NIAID · UNIVERSITY OF VIRGINIA · PI WARREN, CIRLE ALCANTARA · 2014 to 2015
$435k
Novel approaches to develop a treatment for cryptosporidiosisR21AI101381 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D · 2013 to 2014
$419k
NCRR NIH HHS P20 RR021905NIAAA NIH HHS R21 AA030807NIAID NIH HHS K08 AI108730NIAID NIH HHS R21 AI101381NIAID NIH HHS R21 AI111604NIGMS NIH HHS P20 GM125498NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiprotozoal AgentsBenzamidesCryptosporidiosisCryptosporidium parvumDisease Models, AnimalMice, Inbred C57BLNitro CompoundsPyruvate SynthaseThiazolesWeight LossamixicileAntiprotozoal AgentsBenzamidesnitazoxanideNitro CompoundsPyruvate SynthaseThiazolesamixicileCryptosporidiumenvironmental enteropathymalnutritionnitazoxanide

Identifiers

PMID30297368
PMCPMC6256802
OpenAlexW2894604419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.