Evidence map›Paper›PMID 30297330›Full record

ArticleAnnals of the rheumatic diseases2019

Why did IL-23p19 inhibition fail in AS: a tale of tissues, trials or translation?

Stefan Siebert, Neal L Millar, Iain B McInnes

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Stefan SiebertInstitute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Neal L MillarInstitute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Iain B McInnesInstitute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, UK iain.mcinnes@glasgow.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Arthritis, PsoriaticGenomicsHumansInterleukin-17Interleukin-23 Subunit p19Synovial MembraneInterleukin-17Interleukin-23 Subunit p19cytokinesDMARDs (biologic)spondyloarthritis

Identifiers

PMID30297330
PMCPMC6691857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.