Evidence map›Paper›PMID 30297303›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2018

Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor.

Jonathan S Marchant, Wayne W Harding, John D Chan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Machine learningRSC advances · 2021
    Article
  5. Review
  6. Emerging biosensors in detection of natural products.Synthetic and systems biotechnology · 2020
    Review
  7. Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni.International journal for parasitology. Drugs and drug resistance · 2020
    Article
  8. Review
  9. Anthelmintics - From Discovery to Resistance III (Indian Rocks Beach, FL, 2018).International journal for parasitology. Drugs and drug resistance · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jonathan S MarchantDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, 533226, USA.
Wayne W HardingChemistry Department, Hunter College, City University of New York, New York, NY, 10065, USA; Ph.D. Program in Chemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY, 10016, USA; Ph.D. Program in Biochemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY, 10016, USA.
John D ChanDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, 533226, USA. Electronic address: jdchan@mcw.edu.
Medical College of Wisconsin · USThe Graduate Center, CUNY · US

Funding

Structure-activity relationship studies on NantenineSC1GM092282 · NIGMS · HUNTER COLLEGE · PI HARDING, WAYNE WESLEY · 2012 to 2015
$1.2M
(Re)generating new drug leads for schistosomiasisR21AI125821 · NIAID · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S · 2016 to 2018
$425k
A pharmacological screen for 'inactivating antagonists' at an essential parasite G protein coupled receptorR21AI130642 · NIAID · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S · 2017 to 2018
$422k
NIAID NIH HHS HHSN272201000005CNIAID NIH HHS HHSN272201000005INIAID NIH HHS R21 AI125821NIAID NIH HHS R21 AI130642NIGMS NIH HHS SC1 GM092282
6 · The paper itself

Abstract

Serotonin (5-HT) is an important regulator of numerous aspects of flatworm biology, ranging from neuromuscular function to sexual maturation and egg laying. In the parasitic blood fluke Schistosoma mansoni, 5-HT targets several G-protein coupled receptors (GPCRs), one of which has been demonstrated to couple to cAMP and regulate parasite movement. This receptor, Sm.5HTR

Indexed as

AlkaloidsAnimalsBiological ProductsFemaleHEK293 CellsHumansMiceReceptors, G-Protein-CoupledReceptors, SerotoninSchistosoma mansoniSchistosomiasisSerotoninSerotonin AntagonistsAlkaloidsBiological ProductsReceptors, G-Protein-CoupledReceptors, SerotoninSerotoninSerotonin AntagonistsAporphineBenzylisoquinolineG protein coupled receptorProtoberberineSchistosomiasisTryptamine

Identifiers

PMID30297303
PMCPMC6287472
OpenAlexW2894451602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.