Evidence map›Paper›PMID 30297082›Full record

ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2018

The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation.

Michal L Melamed, Michel Chonchol, Orlando M Gutiérrez, Kamyar Kalantar-Zadeh, Jessica Kendrick, Keith Norris, Julia J Scialla, Ravi Thadhani

Abstract readReview
In one paragraph

Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Differential effects of phosphate binders on vitamin D metabolism in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Trial
  2. Article
  3. Review
  4. Current Controversies on Adequate Circulating Vitamin D Levels in CKD.International journal of molecular sciences · 2025
    Review
  5. The role of nutritional vitamin D in chronic kidney disease-mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation-a European consensus statement.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  6. Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism.The Journal of clinical endocrinology and metabolism · 2025 · on this map
    Article
  7. Review
  8. Population Pharmacokinetic Model of Vitamin DInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism.medRxiv : the preprint server for health sciences · 2024
    Article
  12. Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michal L MelamedAlbert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY. Electronic address: michal.melamed@einstein.yu.edu.
Michel ChoncholUniverity of Colorado Denver, Aurora, CO.
Orlando M GutiérrezUniversity of Alabama at Birmingham, Birmingham, AL.
Kamyar Kalantar-ZadehUniversity of California-Irvine, Orange.
Jessica KendrickUniverity of Colorado Denver, Aurora, CO.
Keith NorrisUniversity of California-Los Angeles, Los Angeles, CA.
Julia J SciallaDuke University School of Medicine, Durham, NC.
Ravi ThadhaniMassachusetts General Hospital, Boston, MA; Cedars-Sinai Medical Center, Los Angeles, CA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI HARAWA, NINA THAWATA, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
Bicarbonate Administration In CKDR01HL132868 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KENDRICK, JESSICA B · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR002556NHLBI NIH HHS R01 HL132868NIA NIH HHS P30 AG021684NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

Deficiency of 25-hydroxyvitamin D (25[OH]D) is common in patients with chronic kidney disease stages 3 and 4 and is associated with poor outcomes. However, the evaluation and management of vitamin D deficiency in nephrology remains controversial. This article reports on the proceedings from a "controversies conference" on vitamin D in chronic kidney disease that was sponsored by the National Kidney Foundation. The report outlines the deliberations of the 3 work groups that participated in the conference. Until newer measurement methods are widely used, the panel agreed that clinicians should classify 25(OH)D "adequacy" as concentrations > 20ng/mL without evidence of counter-regulatory hormone activity (ie, elevated parathyroid hormone). The panel also agreed that 25(OH)D concentrations < 15ng/mL should be treated irrespective of parathyroid hormone level. Patients with 25(OH)D concentrations between 15 and 20ng/mL may not require treatment if there is no evidence of counter-regulatory hormone activity. The panel agreed that nutritional vitamin D (cholecalciferol, ergocalciferol, or calcifediol) should be supplemented before giving activated vitamin D compounds. The compounds need further study evaluating important outcomes that observational studies have linked to low 25(OH)D levels, such as progression to end-stage kidney disease, infections, fracture rates, hospitalizations, and all-cause mortality. We urge further research funding in this field.

Indexed as

Dietary SupplementsDisease ProgressionEducationFemaleHumansKidney Failure, ChronicMaleParathyroid HormonePrognosisRenal Insufficiency, ChronicRisk AssessmentSocieties, MedicalVitamin DVitamin D Deficiency25-hydroxyvitamin DParathyroid HormoneVitamin D24;25-dihydroxyvitamin D (24;25[OH](2)D)25-hydroxyvitamin D (25[OH]D)chronic kidney disease (CKD)mineral and bone disorder (MBD)racial differencesrenal osteodystrophysecondary hyperparathyroidism (SHPT)Vitamin Dvitamin D deficiencyvitamin D metabolite ratio (VMR)vitamin D repletion

Identifiers

PMID30297082
PMCPMC6615058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.