Evidence map›Paper›PMID 30296894›Full record

ArticleJournal of clinical and experimental neuropsychology2019

Neuropsychological predictors of patient-reported cognitive decline after deep brain stimulation in Parkinson's disease.

Kelly A Mills, Kristyn Donohue, Aathman Swaminathan, Jeannie-Marie Leoutsakos, Gwenn Smith, Jason Brandt

Abstract read
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In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kelly A Millsa Department of Neurology , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.ORCID 0000-0002-4302-1501
Kristyn Donohueb Department of Psychiatry & Behavioral Sciences , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Aathman Swaminathana Department of Neurology , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Jeannie-Marie Leoutsakosb Department of Psychiatry & Behavioral Sciences , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Gwenn Smithb Department of Psychiatry & Behavioral Sciences , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Jason Brandta Department of Neurology , The Johns Hopkins University School of Medicine , Baltimore , MD , USA.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Molecular Imaging of the Nicotinic Cholinergic Receptor in Parkinson's disease (PD): Implication of for understanding the neurobiology of cognitive impairmentK23NS101096 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLS, KELLY ALEXANDER · 2017 to 2021
$1000k
NCATS NIH HHS KL2 TR001077NCATS NIH HHS UL1 TR001079NINDS NIH HHS K23 NS101096NINDS NIH HHS L30 NS093521
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) is effective for treatment of motor complications of dopaminergic therapy in Parkinson's disease (PD) but occasionally has been associated with multidomain cognitive decline. Patient- and caregiver-reported cognitive decline are clinically meaningful and increasingly recognized as important to consider when evaluating therapeutic interventions for PD.

objectiveThe objective was to assess presurgical neuropsychological and clinical factors associated with PD patient- and caregiver-reported cognitive decline in two or more domains after DBS.

methodA single telephone survey was used to assess patient- and caregiver-reported cognitive decline in five domains at both one and four months after DBS surgery. Decline in two or more domains was considered multidomain cognitive decline (MDCD). Baseline demographic, clinical, and neuropsychological factors were compared in those with or without MDCD. Preoperative neuropsychological measures were evaluated as risk factors and regressed on the presence of MDCD, with demographic covariates, using multiple logistic regression.

resultsPreoperative performance in verbal recognition memory, language knowledge, and verbal processing decline were associated with postoperative, patient-reported MDCD in the first four weeks. MDCD at four months after DBS was associated with worse preoperative verbal reasoning, verbal recall, and semantic verbal fluency. Caregiver-reported MDCD one month after DBS was associated with poorer baseline verbal memory recognition accuracy/discriminability, visuospatial problem solving, and constructional praxis.

conclusionPoor presurgical performance in verbal memory recognition, language processing, and visuospatial performance is associated with patient- or caregiver-reported decline following DBS surgery. Posterior cortical dysfunction seems to portend significant self-reported cognitive decline following deep brain stimulation.

Indexed as

AgedCognitive DysfunctionDeep Brain StimulationFemaleHumansLanguageMaleMemoryMiddle AgedNeuropsychological TestsParkinson DiseaseProblem SolvingRisk FactorsSubthalamic NucleusCognitive impairmentdeep brain stimulationneuropsychologyParkinson’s disease

Identifiers

PMID30296894
PMCPMC6380950

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.