Evidence map›Paper›PMID 30296885›Full record

ArticleScandinavian journal of primary health care2018

Quality assessment in general practice: diagnosis and antibiotic treatment of acute respiratory tract infections.

Laura Trolle Saust, Lars Bjerrum, Volkert Siersma, Magnus Arpi, Malene Plejdrup Hansen

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scandinavian journal of primary health care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07030855 (Assessing the Efficacy of Elixirium Thymi Compositum in the Treatment of Acute Bronchitis in Pediatric Patients), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07030855 phase4enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Assessing the Efficacy of Elixirium Thymi Compositum in the Treatment of Acute Bronchitis in Pediatric Patients (EXOTIC): A Double-blind, Randomized, Placebo-controlled, Phase 4 Study

TypeinterventionalSponsorSemmelweis UniversityRan2025 to 2027Enrolled56ConditionsAcute BronchitisArmsElixirium thymi compositum (FoNo VIII.), Elixirium thymi compositum (FoNo VIII.) placebo
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  3. Group C beta hemolyticScandinavian journal of primary health care · 2020
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  18. Increased antimicrobial resistance during the COVID-19 pandemic.International journal of antimicrobial agents · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Laura Trolle Sausta Department of Clinical Microbiology, Herlev and Gentofte Hospital , University of Copenhagen , Herlev , Denmark.
Lars Bjerrumb Section of General Practice and Research Unit for General Practice, Department of Public Health , University of Copenhagen , Copenhagen , Denmark.
Volkert Siersmab Section of General Practice and Research Unit for General Practice, Department of Public Health , University of Copenhagen , Copenhagen , Denmark.
Magnus Arpia Department of Clinical Microbiology, Herlev and Gentofte Hospital , University of Copenhagen , Herlev , Denmark.
Malene Plejdrup Hansenc Research Unit for General Practice, Department of Clinical Medicine , Aalborg University , Aalborg , Denmark.
Gentofte Hospital · DKUniversity of Copenhagen · DKAalborg University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate areas in need of quality improvement within the diagnostic process and antibiotic treatment of acute respiratory tract infections (RTIs) in Danish general practice by using quality indicators (QIs). DESIGN AND

settingDuring a 4-week period in winter 2017, a prospective registration of patients diagnosed with RTIs was conducted in general practice in two regions of Denmark. SUBJECTS: Throughout the registration period each patient with symptoms of an RTI was registered. Information about age, symptoms and findings, duration of symptoms, the use and result of clinical tests, allergy towards penicillin, referral to secondary care and the antibiotic given were recorded.

main outcome measuresValues and acceptable ranges for QIs focusing on the diagnostic process, the decision to prescribe antibiotics and the choice of antibiotics for patients with RTIs.

resultsRegarding the diagnostic process nearly all QIs for patients diagnosed with acute pharyngotonsillitis and pneumonia fell within the acceptable range. Contrarily, the diagnostic QIs for patients with acute otitis media and acute rhinosinusitis were outside the acceptable range. All indicators designed to measure overuse of antibiotics were outside the acceptable range and nearly all indicators assessing if patients were sufficiently treated fell within the acceptable range. QIs assessing use of the recommended type of antibiotic were only within the acceptable range for patients diagnosed with acute pharyngotonsillitis.

conclusionThe findings indicate an overuse of antibiotics for RTIs in Danish general practice. Especially management of acute rhinosinusitis and acute bronchitis should be targeted in future quality improvement projects. KEY POINTS: To improve antibiotic prescribing in general practice it is important to focus on both the diagnostic process and the prescribing patterns. The findings indicate an overuse of antibiotics for acute respiratory tract infections in Danish general practice. Especially the diagnostic process and antibiotic prescribing patterns for acute rhinosinusitis and acute bronchitis could benefit from future quality improvement interventions.

Indexed as

Quality Indicators, Health CareAcute DiseaseAdolescentAdultAgedAnti-Bacterial AgentsChildChild, PreschoolDenmarkFemaleGeneral PracticeHumansInappropriate PrescribingMaleMiddle AgedPractice Patterns, Physicians'Anti-Bacterial AgentsAntibioticsdiagnosisgeneral practiceprimary carequality assessmentquality indicatorrespiratory tract infections

Identifiers

PMID30296885
PMCPMC6381521
OpenAlexW2897770294

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.