ArticleJournal of empirical research on human research ethics : JERHRE2018
Healthy Volunteers' Perceptions of the Benefits of Their Participation in Phase I Clinical Trials.
Article in Journal of empirical research on human research ethics : JERHRE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethical Considerations in Research With People From Refugee and Asylum Seeker Backgrounds: A Systematic Review of National and International Ethics Guidelines.Journal of bioethical inquiry · 2024Pooled it
- More than a moment: Evolving decisions among eligible volunteers in phase 1 COVID-19 vaccine trials.Human vaccines & immunotherapeutics · 2026Article
- Assessment of Participant Satisfaction and Overall Experience: A Cross-Sectional Survey to Inform Trial Conduct.Patient preference and adherence · 2026Article
- Characteristics of clinical trials associated with appeal and return on investment to participants: a review and framework.The oncologist · 2025Review
- Public Perception of Clinical Trials and Its Predictors Among Polish Adults.Journal of clinical medicine · 2025Article
- Healthy participant engagement in early clinical trials: results from the European EUFEMED survey.Frontiers in pharmacology · 2025Article
- Article
- Does financial compensation matter for research participation in prevention trials in Tanzania? Perspectives of healthy volunteers.PloS one · 2025Article
- Adapting a Research and Community Capacity-Building Program to Address Rural Cancer Burden and Facilitate Partnership Development Between Rural Community Stakeholders and an Urban Comprehensive Cancer Center.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Article
- "Death and Taxes": Why Financial Compensation for Research Participants is an Economic and Legal Risk.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2023Article
- Why not? Motivations for entering a volunteer register for clinical trials during the COVID-19 pandemic.European journal of clinical pharmacology · 2022Article
- Perception of clinical research among patients and healthy volunteers of clinical trials.European journal of clinical pharmacology · 2022Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- The ethical anatomy of payment for research participants.Medicine, health care, and philosophy · 2022Article
- Ethical considerations around volunteer payments in a malaria human infection study in Kenya: an embedded empirical ethics study.BMC medical ethics · 2022Article
- Article
- Call to Action for Enhanced Equity and Inclusion in Cannabis Research.Cannabis and cannabinoid research · 2021Article
- The motivations, barriers, and sociodemographic characteristics of healthy Chinese volunteers in phase I research.European journal of clinical pharmacology · 2021Article
- Healthy volunteers in US phase I clinical trials: Sociodemographic characteristics and participation over time.PloS one · 2021Article
- Speculating on Precarious Income: Finance Cultures and the Risky Strategies of Healthy Volunteers in Clinical Drug Trials.Journal of cultural economy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Other than the financial motivations for enrolling in Phase I trials, research on how healthy volunteers perceive the benefits of their trial participation is scant. Using qualitative interviews conducted with 178 U.S. healthy volunteers enrolled in Phase I trials, we investigated how participants described the benefits of their study involvement, including, but not limited to, the financial compensation, and we analyzed how these perceptions varied based on participants' sociodemographic characteristics and clinical trial history. We found that participants detailed economic, societal, and noneconomic personal benefits. We also found differences in participants' perceived benefits based on gender, age, ethnicity, educational attainment, employment status, and number of clinical trials completed. Our study indicates that many healthy volunteers believe they gain more than just the financial compensation when they accept the risks of Phase I participation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.