ArticleJournal of enzyme inhibition and medicinal chemistry2018
Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.
Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- 1,3-Diaryl Triazenes Incorporating Disulfonamides Show Both Antiproliferative Activity and Effective Inhibition of Tumor-associated Carbonic Anhydrases IX and XII.Anti-cancer agents in medicinal chemistry · 2024Article
- Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- 1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2022Article
- Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX.Scientific reports · 2022Article
- Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors.Scientific reports · 2022Article
- 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- A structure-based approach towards the identification of novel antichagasic compounds:Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Benzothiazole derivatives as anticancer agents.Journal of enzyme inhibition and medicinal chemistry · 2020Review
- Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid-sulphonamide conjugates.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Coumarins fromJournal of enzyme inhibition and medicinal chemistry · 2020Article
- A class of carbonic anhydrase IX/XII - selective carboxylate inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of new 1,3-diaryltriazene sulfonamides was synthesised by reaction of diazonium salt of metanilamide (3-aminobenzene sulfonamide) with substituted aromatic amines. The obtained new compounds were assayed as inhibitors of four physiologically and pharmacologically relevant human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1), specifically, hCA I, hCA II, and hCA VII (cytosolic isoforms), as well as the tumour-associated membrane-bound isoform hCA IX. All isoforms investigated here were inhibited by the newly synthesised 1,3-diaryltriazene sulfonamide derivatives from the micromolar to the nanomolar range. The cytosolic isoforms were inhibited with K
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