Evidence map›Paper›PMID 30296759›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2018

Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior.

Akhgar Ghassabian, Erin M Bell, Wan-Li Ma, Rajeshwari Sundaram, Kurunthachalam Kannan, Germaine M Buck Louis, Edwina Yeung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Determinants of maternal and neonatal PFAS concentrations: a review.Environmental health : a global access science source · 2023
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  7. Cohort Profile: Upstate KIDS study.International journal of epidemiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Akhgar GhassabianDepartments of Pediatrics, New York University School of Medicine, 403 East 34th St, New York, NY, USA; Department of Environmental Medicine, New York University School of Medicine, 403 East 34th St, New York, NY, USA; Department of Population Health, New York University School of Medicine, 403 East 34th St, New York, NY, USA. Electronic address: akhgar.ghassabian@nyulangone.org.
Erin M BellDepartment of Environmental Health Sciences, University at Albany, State University of New York, GEC 149, One University Place, Rensselaer, Albany, NY, USA; Epidemiology and Biostatistics, University at Albany, State University of New York, GEC 149, One University Place, Rensselaer, Albany, NY, USA. Electronic address: ebell@albany.edu.
Wan-Li MaInternational Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China. Electronic address: mawanli002@163.com.
Rajeshwari SundaramBiostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Dr., MSC 7004, Bethesda, MD, USA. Electronic address: sundaramr2@mail.nih.gov.
Kurunthachalam KannanDepartment of Environmental Health Sciences, University at Albany, State University of New York, GEC 149, One University Place, Rensselaer, Albany, NY, USA; Wadsworth Center, New York State Department of Health, Department of Environmental Health Sciences, State University of New York at Albany, Empire State Plaza, PO Box 509, Albany, NY, USA. Electronic address: kurunthachalam.kannan@health.ny.gov.
Germaine M Buck LouisDean's Office, College of Health and Human Services, George Mason University, 4400 University Dr., Fairfax, VA, USA. Electronic address: glouis@gmu.edu.
Edwina YeungEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Dr., MSC 7004, Bethesda, MD, USA. Electronic address: Edwina.yeung@nih.gov.
Albany State University · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USGeorge Mason University · USHarbin Institute of Technology · CNNational Institutes of Health · USNew York University · US

Funding

Infertility Treatment, Child Growth and Development Through Age Three YearsZIAHD008826 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2009 to 2025
$9.4M
Upstate KIDS Follow-Up StudyZIAHD008949 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YEUNG, EDWINA · 2015 to 2025
$4.8M
NICHD NIH HHS HHSN267200700019CNICHD NIH HHS HHSN275201200005CNICHD NIH HHS HHSN275201300026INICHD NIH HHS HHSN275201400013C
6 · The paper itself

Abstract

Experimental studies suggest that prenatal exposure to endocrine disrupting chemicals interferes with developmental processes in the fetal brain. Yet, epidemiological evidence is inconclusive. In a birth cohort (2008-2010, upstate New York), we quantified concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) in stored newborn dried blood spots using liquid chromatography/tandem mass spectrometry. Mothers reported on children's behavior using the Strengths and Difficulties Questionnaire at age 7 (650 singletons and 138 twins). Difficulties in total behavior (i.e., emotional, conduct, hyperactivity, and peer problems) and prosocial behavior were classified using validated cut-offs. We used logistic regression with generalized estimating equations to estimate the odds of having difficulties per exposure category. In total, 111 children (12.1%) had total behavioral difficulties and 60 (6.5%) had difficulties in prosocial behavior. The median (interquartile range) of PFOS, PFOA, and BPA were 1.74 ng/ml (1.33), 1.12 ng/ml (0.96), and 7.93 ng/ml (10.79), respectively. Higher PFOS levels were associated with increased odds of having behavioral difficulties (OR per SD of log PFOS = 1.30, 95%CI: 1.03-1.65). We observed associations between PFOS in the highest relative to the lowest quartile and behavioral difficulties (OR for PFOS

Indexed as

AdultAlkanesulfonic AcidsBenzhydryl CompoundsBisphenol A CompoundsCaprylatesChildChild BehaviorChild, PreschoolChromatography, LiquidDried Blood Spot TestingEndocrine DisruptorsFemaleFluorocarbonsHumansInfant, NewbornLogistic ModelsAlkanesulfonic AcidsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCaprylatesEndocrine DisruptorsFluorocarbonsperfluorooctane sulfonic acidperfluorooctanoic acidPhenolsBehaviorDried blood spotsEndocrine disrupting chemicalsNeonatesPerfluoroalkyl substances

Identifiers

PMID30296759
PMCPMC6221990
OpenAlexW2892869046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.