Evidence map›Paper›PMID 30296735›Full record

ArticleSleep medicine2018

Pain intensity as a moderator of the association between opioid use and insomnia symptoms among adults with chronic pain.

Mary Beth Miller, Wai Sze Chan, Ashley F Curtis, Jeff Boissoneault, Michael Robinson, Roland Staud, Richard B Berry, Christina S McCrae

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Clonidine is better than zopiclone for insomnia treatment in chronic pain patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Observational
  5. Daily associations between sleep and opioid use among adults with comorbid symptoms of insomnia and fibromyalgia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mary Beth MillerDepartment of Psychiatry, University of Missouri School of Medicine, Columbia, MO, USA.
Wai Sze ChanDepartment of Psychology, The University of Hong Kong, Hong Kong, China.
Ashley F CurtisDepartment of Psychiatry, University of Missouri School of Medicine, Columbia, MO, USA.
Jeff BoissoneaultDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Michael RobinsonDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Roland StaudDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Richard B BerryDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Christina S McCraeDepartment of Psychiatry, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address: mccraec@health.missouri.edu.
University of Florida · USUniversity of Florida Health · USUniversity of Missouri · USUniversity of Hong Kong · HKUniversity of Missouri Health System · US

Funding

Sleep and Pain Interventions in Fibromyalgia: Hyperalgesia and Central SensitizatR01AR055160 · NIAMS · UNIVERSITY OF FLORIDA · PI MCCRAE, CHRISTINA S · 2008 to 2012
$1.9M
NIAAA NIH HHS L30 AA025226NIAMS NIH HHS R01 AR055160
6 · The paper itself

Abstract

objectiveResearch documenting the impact of opioid use on sleep among individuals with chronic pain has been mixed. This study aimed to determine if pain intensity moderates the association between opioid use and insomnia symptoms among adults with comorbid symptoms of insomnia and chronic widespread pain.

methodsParticipants (N = 144; 95% female; mean age = 51.6, SD = 11.4) completed assessments of insomnia symptoms, pain and use of sleep/pain medication. Multiple regression was used to determine if pain intensity moderates the association between opioid use (yes/no) sleep onset latency (SOL), wake after sleep onset (WASO), sleep quality, or time in bed. Analyses controlled for gender, symptoms of sleep apnea, symptoms of depression, use of sleep medication (yes/no), and use of non-opioid pain medication (yes/no).

resultsStronger pain intensity was associated with longer self-reported WASO and worse sleep quality, independent of opioid use. Conversely, opioid use was associated with longer time in bed, independent of pain intensity. Opioid use and pain intensity interacted in the prediction of SOL, such that opioid use (vs. non-use) was associated with longer SOL in the context of mild but not moderate to severe pain intensity.

conclusionsOpioid use was associated with more difficulty falling asleep among adults with chronic pain; however, this cross-sectional effect was only significant among those reporting lower pain intensity. Authors speculate that this effect is masked among those with severe pain because the pain-related sleep debt they acquire throughout the night then facilitates sleep onset the next day.

Indexed as

ComorbidityAnalgesics, OpioidChronic PainFemaleHumansMaleMiddle AgedSelf ReportSleep Initiation and Maintenance DisordersSleep LatencyAnalgesics, OpioidFibromyalgiaInsomniaOpioid usePain medicationSleep

Identifiers

PMID30296735
PMCPMC6246793
OpenAlexW2891996806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.