Evidence map›Paper›PMID 30296702›Full record

ArticleRedox biology2019

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease.

Kranti A Mapuskar, Hsiang Wen, Danniele G Holanda, Prerna Rastogi, Emily Steinbach, Rachel Han, Mitchell C Coleman, Massimo Attanasio, Dennis P Riley, Douglas R Spitz and 2 more

Abstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Trial
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. IsKidney medicine · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Effects of a blend extract ofOpen veterinary journal · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kranti A MapuskarDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA, 52242, United States.
Hsiang WenDivision of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242, United States.
Danniele G HolandaDepartment of Pathology, The University of Iowa, Iowa City, IA, 52242, United States.
Prerna RastogiDepartment of Pathology, The University of Iowa, Iowa City, IA, 52242, United States.
Emily SteinbachDivision of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242, United States.
Rachel HanDivision of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242, United States.
Mitchell C ColemanDepartment of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA, 52242, United States.
Massimo AttanasioDepartment of Internal Medicine, The University of Iowa, Iowa City, IA, 52242, United States.
Dennis P RileyGalera Therapeutics, Inc., Malvern, PA, United States.
Douglas R SpitzDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA, 52242, United States.
Bryan G AllenDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA, 52242, United States.
Diana Zepeda-OrozcoDivision of Pediatric Nephrology, Dialysis and Transplantation, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242, United States. Electronic address: diana-zepeda-orozco@uiowa.edu.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Mark E Burkard · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
Molecular and Cellular Research to Advance Childhood HealthK12HD027748 · NICHD · UNIVERSITY OF IOWA · PI ALEXANDER G BASSUK · 2002 to 2026
$9.2M
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem CellsR01CA182804 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 2014 to 2018
$1.7M
NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA182804NICHD NIH HHS K12 HD027748NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Severe and recurrent cisplatin-induced acute kidney injury (AKI) as part of standard cancer therapy is a known risk factor for development of chronic kidney disease (CKD). The specific role of superoxide (O

Indexed as

Acute Kidney InjuryAnimalsBiological MimicryBiopsyCisplatinMaleMiceMitochondriaModels, BiologicalOxidation-ReductionOxidative StressRenal Insufficiency, ChronicSuperoxide DismutaseSuperoxidesCisplatinSuperoxide DismutaseSuperoxidesCisplatinKidney injuryMitochondrial metabolismSuperoxideSuperoxide dismutase mimetic

Identifiers

PMID30296702
PMCPMC6174865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.