ArticleAppetite2019
Dopamine genetic risk is related to food addiction and body mass through reduced reward-related ventral striatum activity.
Article in Appetite, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Sex as a moderator of the relationship between food addiction and body mass index in young non-help-seeking adults at risk for psychosis and controls.Eating and weight disorders : EWD · 2026Article
- Socio-demographic, dietary, exercise, and mental health factors associated with food addiction symptoms in university students.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025Article
- Abstinence-based treatment of comorbid eating disorders and ultra-processed food addiction.Frontiers in psychiatry · 2025Article
- Food Addiction: Prevalence, Severity, and Impact on Vascular Stroke Risk Factors in a French Hospital-Based Sample.Nutrients · 2024Article
- Relationship Between BMI, Self-Rated Depression, and Food Addiction-A Cross-Sectional Study of Adults in Postpandemic Poland.Depression and anxiety · 2024Article
- Association between dopamine genes, adiposity, food addiction, and eating behavior in Chilean adult.Frontiers in nutrition · 2024Article
- Dissociative experiences of compartmentalization are associated with food addiction symptoms: results from a cross-sectional report.Eating and weight disorders : EWD · 2023Article
- Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions.Nutrients · 2023Review
- Food Addiction and Emotional Eating Behaviors Co-Occurring with Problematic Smartphone Use in Adolescents?International journal of environmental research and public health · 2022Article
- Parental reward-based eating drive predicts parents' feeding behaviors and Children's ultra-processed food intake.Appetite · 2021Article
- Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study.International journal of obesity (2005) · 2021Article
- Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task.BMC psychiatry · 2020Article
- Changes in Alcohol Use after Metabolic and Bariatric Surgery: Predictors and Mechanisms.Current psychiatry reports · 2019Review
- Neuroanatomical correlates of food addiction symptoms and body mass index in the general population.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The prevalence rate of obesity continues to rise in the U.S., but effective treatment options remain elusive resulting in increased emphasis on prevention. One such area of prevention research capitalizes on the relatively novel behavioral construct of food addiction, which has been implicated in obesity. Food addiction reflects an individual's propensity for compulsive eating despite negative consequences, and shares not only symptoms with both eating and substance use disorders but also genetic and neural correlates within neural reward-circuitry modulated by dopamine. Here, we examined associations between food addiction scores, body mass index (BMI), reward-related ventral striatum activity, and a polygenic score approximating dopamine signaling in 115 non-Hispanic Caucasian young adult university students. As predicted, polygenic dopamine scores were related to ventral striatum activity, which in turn was associated with higher food addiction scores. In addition, food addiction was related to BMI. An exploratory post-hoc path analysis further indicated that polygenic scores were indirectly related to both food addiction and BMI, in part, through ventral striatum activity. Collectively, our results provide evidence supporting the utility of food addiction in weight gain prevention research by establishing links with known risk-related neural and genetic biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.