ArticleIEEE transactions on bio-medical engineering2019
3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 30 citations in OpenAlex.
- A novel spatiotemporal decomposition and identification of sparse equations for human brain deformation.Scientific reports · 2026Article
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- Comparison of Deformation Patterns Excited in the Human Brain In Vivo by Harmonic and Impulsive Skull Motion.Journal of biomechanical engineering · 2023Article
- Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI.Journal of the mechanical behavior of biomedical materials · 2023Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Group characterization of impact-induced,Journal of the Royal Society, Interface · 2021Article
- Natural oscillatory modes of 3D deformation of the human brain in vivo.Journal of biomechanics · 2021Article
- Integrating material properties from magnetic resonance elastography into subject-specific computational models for the human brain.Brain multiphysics · 2021Article
- Calibration of a Heterogeneous Brain Model Using a Subject-Specific Inverse Finite Element Approach.Frontiers in bioengineering and biotechnology · 2021Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Biomechanical Analysis of Woodpecker Response During Pecking Using a Two-Dimensional Computational Model.Frontiers in bioengineering and biotechnology · 2020Article
- Insights Into Traumatic Brain Injury From MRI of Harmonic Brain Motion.Journal of experimental neuroscience · 2019Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
objectiveTo obtain dense spatiotemporal measurements of brain deformation from two distinct but complementary head motion experiments: linear and rotational accelerations.
methodsThis study introduces a strategy for integrating harmonic phase analysis of tagged magnetic resonance imaging (MRI) and finite-element models to extract mechanically representative deformation measurements. The method was calibrated using simulated as well as experimental data, demonstrated in a phantom including data with image artifacts, and used to measure brain deformation in human volunteers undergoing rotational and linear acceleration.
resultsEvaluation methods yielded a displacement error of 1.1 mm compared to human observers and strain errors between [Formula: see text] for linear acceleration and [Formula: see text] for rotational acceleration. This study also demonstrates an approach that can reduce error by 86% in the presence of corrupted data. Analysis of results shows consistency with 2-D motion estimation, agreement with external sensors, and the expected physical behavior of the brain.
conclusionMechanical regularization is useful for obtaining dense spatiotemporal measurements of in vivo brain deformation under different loading regimes. SIGNIFICANCE: The measurements suggest that the brain's 3-D response to mild accelerations includes distinct patterns observable using practical MRI resolutions. This type of measurement can provide validation data for computer models for the study of traumatic brain injury.
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