ArticleJournal of experimental botany2019
Verticillium dahliae PevD1, an Alt a 1-like protein, targets cotton PR5-like protein and promotes fungal infection.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 88 citations in OpenAlex.
- The MdERF1B-miR482c-Horticulture research · 2026Article
- Conserved protein folds underpin the diversification of secreted proteins in a fungal pathogen.BMC microbiology · 2026Article
- Molecular mechanism of fungal effector PevD1-NRP interaction and discovery of a small-molecule disruptor.The Journal of biological chemistry · 2026Article
- Fungal foe: exploring cotton's physiological responses to Verticillium wilt.Frontiers in plant science · 2026Review
- A fungal pathogen manipulates phytocytokine signaling for plant infection.Nature communications · 2025Article
- Tracking of Tobacco Mosaic Virus in Taxonomically Different Plant Fungi.Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Transcriptome reveals Gafmt-1 and Gadlc-1-5 play positive roles in cotton resistance to Verticillium wilt.Plant cell reports · 2025Article
- Natural SNP Variation in GbOSM1 Promotor Enhances Verticillium Wilt Resistance in Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The heat shock factor 20-HSF4-cellulose synthase A2 module regulates heat stress tolerance in maize.The Plant cell · 2024Article
- Genome-Wide and Expression Pattern Analysis of the HIT4 Gene Family Uncovers the Involvement ofGenes · 2024Article
- The interaction of two Puccinia striiformis f. sp. tritici effectors modulates high-temperature seedling-plant resistance in wheat.Molecular plant pathology · 2023Article
- Tissues and mechanisms associated with Verticillium wilt resistance in tomato using bi-grafted near-isogenic lines.Journal of experimental botany · 2023Article
- Nutritional Provision of Iron Complexes by the Major Allergen Alt a 1 to Human Immune Cells Decreases Its Presentation.International journal of molecular sciences · 2023Article
- LncRNA109897-JrCCR4-JrTLP1b forms a positive feedback loop to regulate walnut resistance against anthracnose caused byHorticulture research · 2023Article
- Botrytis hypersensitive response inducing protein 1 triggers noncanonical PTI to induce plant cell death.Plant physiology · 2023Article
- Interactions betweenFrontiers in plant science · 2023Review
- Transcription Factor VdCf2 Regulates Growth, Pathogenicity, and the Expression of a Putative Secondary Metabolism Gene Cluster in Verticillium dahliae.Applied and environmental microbiology · 2022Article
- Genome-wide analysis of serine carboxypeptidase-like protein (SCPL) family and functional validation of Gh_SCPL42 unchromosome conferring cotton Verticillium der Verticillium wilt stress in Gossypium hirsutum.BMC plant biology · 2022Article
- Ethylene-responsive factor ERF114 mediates fungal pathogen effector PevD1-induced disease resistance in Arabidopsis thaliana.Molecular plant pathology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alt a 1 family proteins (AA1s) have only been observed in the Dothideomycetes and Sordariomycetes classes of fungi, and their biological functions have remained poorly understood. Verticillium dahliae, a soil-borne pathogen that causes plant wilt disease, secretes hundreds of proteins during the process of pathogenic infection, including the AA1 member PevD1. In this study, we found that the pevd1 transcript was present in all of the hosts studied (cotton, Arabidopsis, tomato, and tobacco) and showed elevated expression throughout the infection process. Furthermore, pevd1 knockout mutants displayed attenuated pathogenicity compared with the wild-type (WT) strain and complemented strains in hosts. A partner protein of PevD1, pathogenesis-related protein 5 (PR5)-like protein GhPR5, was isolated from cotton (Gossypium hirsutum) plants by co-purification assays, and the PevD1-GhPR5 interaction was determined to be localized in the C-terminus (PevD1b, amino acids residues 113-155) by pull-down and yeast two-hybrid techniques. Re-introduction of the pevd1b gene into a pevd1 knockout mutant resulted in restoration of the virulence phenotype to WT levels. In addition, PevD1b, which is similar to PevD1, decreased the antifungal activity of GhPR5 in vitro. Our findings reveal an infection strategy in which V. dahliae secretes PevD1 to inhibit GhPR5 antifungal activity in order to overcome the host defence system.
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