ArticleJournal of experimental botany2018
Gnp4/LAX2, a RAWUL protein, interferes with the OsIAA3-OsARF25 interaction to regulate grain length via the auxin signaling pathway in rice.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 103 citations in OpenAlex.
- The Chromatin Remodeler PEL1.2 Coordinates GA/JA Homoeostasis to Promote Panicle Exsertion for Hybrid Rice Seed Production.Plant, cell & environment · 2026Article
- Evolution trajectory of auxin response factor across Triticeae species underpin candidate genes for the regulation of salt/alkali stress responsive networks.Plant cell reports · 2026Article
- Excessive Leaf Rolling Reduces Grain Yield by Disrupting Source-Sink Balance in Rice (Plants (Basel, Switzerland) · 2026Article
- Genome-wide association analysis and molecular marker development for effective tiller number in rice natural population.BMC plant biology · 2026Article
- Identification of QTLs and genes regulating panicle number through genome-wide association studies inFrontiers in plant science · 2026Article
- Surviving desiccation: key factors underlying tolerance in prokaryotes and eukaryotes.Protoplasma · 2025Review
- Transcriptome-Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Natural variation of GNP2 enhances grain number to benefit rice yield.Nature communications · 2025Article
- Elite haplotype of STRONG1 enhances rice yield by improving lodging resistance, panicle and plant architecture.Nature communications · 2025Article
- Auxin meets BR: OsIAA7 teams up with OsGSK2 to destabilize OsBZR1 for rice seed size control.The Plant cell · 2025Article
- Review
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- The natural variation allele OsGSW3.2 in Oryza rufipogon is involved in brassinosteroid signaling and influences grain size and weight.The Plant journal : for cell and molecular biology · 2025Article
- The E3 ligase OsPUB33 controls rice grain size and weight by regulating the OsNAC120-BG1 module.The Plant cell · 2024Article
- Article
- Natural variation in the Tn1a promoter regulates tillering in rice.Plant biotechnology journal · 2024Article
- The OsMAPK5-OsWRKY72 module negatively regulates grain length and grain weight in rice.Journal of integrative plant biology · 2024Article
- OsIAA23 Promotes Heading by Directly Downregulating Ghd7 in rice.Rice (New York, N.Y.) · 2024Article
- Molecular mechanisms controlling grain size and weight and their biotechnological breeding applications in maize and other cereal crops.Journal of advanced research · 2024Review
- OsNAC121 regulates root development, tillering, panicle morphology, and grain filling in rice plant.Plant molecular biology · 2024Article
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grain length is one of the determinants of yield in rice and auxin plays an important role in regulating it by mediating cell growth. Although several genes in the auxin pathway are involved in regulating grain length, the underlying molecular mechanisms remain unclear. In this study we identify a RING-finger and wd40-associated ubiquitin-like (RAWUL) domain-containing protein, Gnp4/LAX2, with a hitherto unknown role in regulation of grain length by its influence on cell expansion. Gnp4/LAX2 is broadly expressed in the plant and subcellular localization analysis shows that it encodes a nuclear protein. Overexpression of Gnp4/LAX2 can significantly increase grain length and thousand-kernel weight. Moreover, Gnp4/LAX2 physically interacts with OsIAA3 and consequently interferes with the OsIAA3-OsARF25 interaction in vitro and in vivo. OsIAA3 RNAi plants consistently exhibit longer grains, while the mutant osarf25 has small grains. In addition, OsARF25 binds to the promoter of OsERF142/SMOS1, a regulator of organ size, and positively regulates its expression. Taken together, the results reveal that Gnp4/LAX2 functions as a regulator of grain length through participation in the OsIAA3-OsARF25-OsERF142 pathway and that it has potential value for molecular breeding in rice.
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