ArticleCerebral cortex (New York, N.Y. : 1991)2019
Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Prenatal exposure to hypertensive disorders and adolescent brain white matter development.Pediatric research · 2026Article
- Nucleus Accumbens Hyperactivity and mPFC-NAc Circuit Dysfunction Promote Self-Injurious Behavior in Rats.International journal of molecular sciences · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Amphetamine in adolescence induces a sex-specific mesolimbic dopamine phenotype in the adult prefrontal cortex.Communications biology · 2025Article
- Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks.Molecular psychiatry · 2025Review
- Article
- Divergent outcomes of delta 9 - tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice.Psychopharmacology · 2025Article
- Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.BMC psychiatry · 2025Article
- Article
- Developmental dynamics of marmoset prefrontal cortical SST and PV interneuron networks highlight primate-specific features.Development (Cambridge, England) · 2025Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state.Nature communications · 2024Article
- Article
- Developmental dynamics of the prefrontal cortical SST and PV interneuron networks: Insights from the monkey highlight human-specific features.bioRxiv : the preprint server for biology · 2024Article
- Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse.The European journal of neuroscience · 2024Article
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions.Scientific reports · 2024Article
- Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice.Journal of visualized experiments : JoVE · 2024Article
- Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.Biological psychiatry · 2024Article
- How life events may confer vulnerability to addiction: the role of epigenetics.Frontiers in molecular neuroscience · 2024Review
- Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.Brain structure & function · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Psychiatric conditions marked by impairments in cognitive control often emerge during adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and functional maturation and are vulnerable to disruption by external events. It is not known, however, whether there exists a specific temporal window within the broad range of adolescence when the development of PFC circuitry and its related behaviors are sensitive to disruption. Here we show, in male mice, that repeated exposure to amphetamine during early adolescence leads to impaired behavioral inhibition, aberrant PFC dopamine connectivity, and reduced PFC dopamine function in adulthood. Remarkably, these deficits are not observed following exposure to the exact same amphetamine regimen at later times. These findings demonstrate that there is a critical period for the disruption of the adolescent maturation of cognitive control and PFC dopamine function and suggest that early adolescence is particularly relevant to the emergence of psychopathology in humans.
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