Evidence map›Paper›PMID 30295172›Full record

ArticleTechnology in cancer research & treatment2018

Critical Appraisal of the Treatment Planning Performance of Volumetric Modulated Arc Therapy by Means of a Dual Layer Stacked Multileaf Collimator for Head and Neck, Breast, and Prostate.

Luca Cozzi, Antonella Fogliata, Stephen Thompson, Ciro Franzese, Davide Franceschini, Fiorenza de Rose, Stefano Tomatis, Marta Scorsetti

Open access · goldAbstract read
In one paragraph

Article in Technology in cancer research & treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Craniospinal irradiation planning and delivery: a comparison between Halcyon Ring Gantry and TrueBeam C Arm LINAC delivery systems.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  3. Quantification of Lung Tumor Motion and Optimization of Treatment.Journal of biomedical physics & engineering · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Luca Cozzi1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.ORCID 0000-0001-7862-898X
Antonella Fogliata1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
Stephen Thompson3 Varian Medical Systems, Palo Alto, CA, USA.
Ciro Franzese1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
Davide Franceschini1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
Fiorenza de Rose1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
Stefano Tomatis1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
Marta Scorsetti1 Radiotherapy and Radiosurgery Department, Humanitas Research Hospital, Milan-Rozzano, Italy.
IRCCS Humanitas Research Hospital · ITHumanitas University · ITVarian Medical Systems (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo ascertain whether a new delivery system (the Halcyon system) equipped with dual-layer stacked multileaf collimator operating in a mode, which allows independent, fully interdigitating motion of both layers and 6 flattening filter free energy, could generate plans of high clinical quality compared to a well-established delivery system with single layer multileaf collimator.

methodsTwenty patients in each of the 3 groups (advanced head and neck, breast, and high-risk prostate) were selected for an in silico planning study. For each patient, reference plans were developed for volumetric modulated arc therapy technique with 6 MV photon beams from a TrueBeam linear accelerator and compared against the corresponding plans for the Halcyon system. Plan comparison was performed in terms of dose volume histogram quantitative analysis.

resultsConcerning the planning target volumes, with identical dose calculation and optimization algorithms and with identical planning techniques, no clinically relevant difference in coverage (D

conclusionThe data presented confirmed that the new delivery system can generate treatment plans for volumetric modulated arc therapy with the same dosimetric quality of what is achievable with other systems routinely used in the clinics without significantly changing the current practice. Additional studies which customize the optimization parameters for each delivery device would complement the spectrum of investigations.

Indexed as

Particle AcceleratorsRadiotherapy Planning, Computer-AssistedBreast NeoplasmsFemaleHead and Neck NeoplasmsHumansMaleProstatic NeoplasmsRadiation DosimetersRadiotherapy DosageRadiotherapy, Intensity-Modulatedbreastdual-layer MLChalcyonhead and neckprostateRapidArcVMAT

Identifiers

PMID30295172
PMCPMC6176542
OpenAlexW2897190286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.