Evidence map›Paper›PMID 30294968›Full record

ReviewImmunological reviews2018

Thinking differently about ILCs-Not just tissue resident and not just the same as CD4

Yuefeng Huang, Kairui Mao, Ronald N Germain

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Regulation of innate lymphoid cell by microbial metabolites.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  4. Review
  5. The role of CD56Journal of neuroinflammation · 2024
    Review
  6. Review
  7. Review
  8. Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Innate Lymphoid Cells in Human Pregnancy.Frontiers in immunology · 2020
    Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yuefeng HuangLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National institute of Health, Bethesda, Maryland.
Kairui MaoLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National institute of Health, Bethesda, Maryland.
Ronald N GermainLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National institute of Health, Bethesda, Maryland.
National Institute of Allergy and Infectious Diseases · USColumbia University · US

Funding

Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4M
Analysis of Host-Pathogen InteractionsZIAAI001034 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2021
$7.9M
The generation, migration and function of inflammatory ILC2sR00AI123350 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, YUEFENG · 2019 to 2020
$498k
NIAID K99 Award 1K99AI123350-01A1NIAID NIH HHS R00 AI123350
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) resemble adaptive T lymphocytes based on transcription factor expression, cytokine production, and their presumptive roles in immunity, but are activated for effector function through cytokine signaling and not antigen-specific receptors. The prevailing view is that ILCs adapt to specific microenvironments during development and operate as tissue-resident cells in co-operation with antigen-specific T cells to provide host protection and contribute to tissue maintenance. In particular, conventional models equate the activity of different ILC subsets with CD4

Indexed as

Adaptive ImmunityAnimalsCell MovementHomeostasisHumansImmunity, InnateInfectionsIntestinal MucosaLungLymphocytesMicrobiotaTh17 Cellshost-pathogen interactioninnate lymphoid cellsmucosa

Identifiers

PMID30294968
PMCPMC6945770
OpenAlexW2896061093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.