Evidence map›Paper›PMID 30294750›Full record

ArticleJournal of computational neuroscience2018

Linear-nonlinear-time-warp-poisson models of neural activity.

Patrick N Lawlor, Matthew G Perich, Lee E Miller, Konrad P Kording

Abstract read
In one paragraph

Article in Journal of computational neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  4. Myelin-Proteinoids Interactions in Neural Signaling.Langmuir : the ACS journal of surfaces and colloids · 2025
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  5. ADA: A decoding algorithm for temporally-variable brain responses.Computational and structural biotechnology journal · 2025
    Article
  6. Spectral Learning of Shared Dynamics Between Generalized-Linear Processes.Advances in neural information processing systems · 2024
    Article
  7. Article
  8. Motor Cortex Latent Dynamics Encode Spatial and Temporal Arm Movement Parameters Independently.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Modeling and dissociation of intrinsic and input-driven neural population dynamics underlying behavior.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Scanning behaviour in ants: an interplay between random-rate processes and oscillators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Patrick N LawlorDivision of Child Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. lawlorp1@email.chop.edu.ORCID 0000-0001-7621-3254
Matthew G PerichUniversity of Geneva, Geneva, Switzerland.
Lee E MillerDepartment of Physiology, Northwestern University, Chicago, IL, USA.
Konrad P KordingDepartments of Bioengineering and Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Children's Hospital of Philadelphia · USNorthwestern University · USUniversity of Geneva · CHUniversity of Pennsylvania · US

Funding

SYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2003 to 2018
$19.2M
PATHOPHYSIOLOGY AND REHABILITATION OF NEURAL DYSFUNCTIONT32HD007418 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Levi John Hargrove · 1992 to 2026
$6.5M
General Motor Control Mechanisms and Disease Training ProgramT32NS041234 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BEVAN, MARK D · 2001 to 2022
$6.0M
Neural Mechanisms of Fixation Choice While Searching Natural ScenesR01EY021579 · NEI · NORTHWESTERN UNIVERSITY · PI KORDING, KONRAD P., SEGRAVES, MARK A · 2012 to 2019
$2.8M
The representation of uncertainty in the sensorimotor systemR01NS074044 · NINDS · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI KORDING, KONRAD P., MILLER, LEE · 2011 to 2015
$1.6M
Motor Cortical Function During Motor Learning with a Brain-Machine InterfaceF31NS092356 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERICH, MATTHEW GEORGE · 2015 to 2017
$93k
NEI NIH HHS R01 EY021579NICHD NIH HHS T32 HD007418NINDS NIH HHS F31 NS092356NINDS NIH HHS NIH R01 MH103910NINDS NIH HHS NIH T32 NS047085NINDS NIH HHS R01 NS074044NINDS NIH HHS T32 NS041234
6 · The paper itself

Abstract

Prominent models of spike trains assume only one source of variability - stochastic (Poisson) spiking - when stimuli and behavior are fixed. However, spike trains may also reflect variability due to internal processes such as planning. For example, we can plan a movement at one point in time and execute it at some arbitrary later time. Neurons involved in planning may thus share an underlying time course that is not precisely locked to the actual movement. Here we combine the standard Linear-Nonlinear-Poisson (LNP) model with Dynamic Time Warping (DTW) to account for shared temporal variability. When applied to recordings from macaque premotor cortex, we find that time warping considerably improves predictions of neural activity. We suggest that such temporal variability is a widespread phenomenon in the brain which should be modeled.

Indexed as

Models, NeurologicalNonlinear DynamicsAction PotentialsAnimalsHumansNeuronsPoisson DistributionTime FactorsGeneralized linear modelModelingPoisson processReaching movementsSpike trains

Identifiers

PMID30294750
PMCPMC6409107
OpenAlexW2789995459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.