Evidence map›Paper›PMID 30294720›Full record

ArticleEClinicalMedicine2018

Evaluating Effectiveness of Mass and Continuous Long-lasting Insecticidal Net Distributions Over Time in Madagascar: A Sentinel Surveillance Based Epidemiological Study.

Florian Girond, Yoann Madec, Thomas Kesteman, Milijaona Randrianarivelojosia, Rindra Randremanana, Lea Randriamampionona, Laurence Randrianasolo, Maherisoa Ratsitorahina, Vincent Herbreteau, Judith Hedje and 2 more

Abstract read
In one paragraph

Article in EClinicalMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Florian GirondEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.
Yoann MadecEmerging Diseases Epidemiology Unit, Institut Pasteur, 25-28, rue du Docteur Roux, 75015 Paris, France.
Thomas KestemanUnite de Recherche sur le Paludisme, Institut Pasteur de Madagascar, BP 1274, Avaradoha, Antananarivo 101, Madagascar.
Milijaona RandrianarivelojosiaUnite de Recherche sur le Paludisme, Institut Pasteur de Madagascar, BP 1274, Avaradoha, Antananarivo 101, Madagascar.
Rindra RandremananaEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.
Lea RandriamampiononaEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.
Laurence RandrianasoloEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.
Maherisoa RatsitorahinaEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.
Vincent HerbreteauUMR 228 ESPACE-DEV (IRD, UAG, UM, UR), Station SEAS-OI, 40 avenue de Soweto, 97410 Saint Pierre, France.
Judith HedjeMalaria Branch, Division of Parasitic Diseases and Malaria, Center fo r Global Health, US Centers fo r Disease Control and Prevention, Atlanta, CA, USA.
Christophe RogierInstitut Pasteur de Madagascar, Antananarivo, Madagascar.
Patrice PiolaEpidemiology Unit, Institut Pasteur de Madagascar, BP 1274 Avaradoha, Antananarivo 101, Madagascar.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundThe reduction of global malaria burden over the past 15 years is much attributed to the expansion of mass distribution campaigns (MDCs) of long-lasting insecticidal nets (LLIN). In Madagascar, two LUN MDCs were implemented and one district also benefited from a community-based continuous distribution (CB-CD). Malaria incidence dropped but eventually rebounded after a decade.

methodsData from a sentinel surveillance network over the 2009-2015 period was analyzed. Alerts were defined as w eekly number o f malaria cases exceeding the 90th percentile value for three consecutive weeks. Statistical analyses assessed the temporal relationship between LLIN MDCs and (i) number of malaria cases and (ii) malaria alerts detected, and (iii) the effect of a combination of MDCs and a CB-CD in Toamasina District.

findingsAnalyses showed an increase of 13.6 points and 21.4 points in the percentile value of weekly malaria cases during the second and the third year following the MDC of LLINs respectively. The percentage of alert-free sentinel sites was 98.2% during the first year after LLIN MDC, 56.7% during the second year and 31.5% during the third year. The number of weekly malaria cases decreased by 14% during the CB-CD in Toamasina District. In contrast, sites without continuous distribution had a 12% increase of malaria cases.

interpretationThese findings support the malaria-preventive effectiveness of MDCs in Madagascar but highlight their limited duration when not followed by continuous distribution. The resulting policy implications are crucial to sustain reductions in malaria burden in high transmission settings.

Indexed as

LLINs effectivenessMadagascarMalariaSentinel surveillance

Identifiers

PMID30294720
PMCPMC6169794

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.