Evidence map›Paper›PMID 30294709›Full record

ArticleJournal of patient-reported outcomes2018

The relationship between comorbidity medication adherence and health related quality of life among patients with cancer.

Dana Drzayich Antol, Adrianne Waldman Casebeer, Raya Khoury, Todd Michael, Andrew Renda, Sari Hopson, Aparna Parikh, Alisha Stein, Mary Costantino, Stephen Stemkowski and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in Journal of patient-reported outcomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Influence of reminiscence therapy on mental health and quality of life in elderly patients with unresectable, metastatic gastrointestinal cancer.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
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  14. Impact of depression on adherence to lenalidomide plus low-dose dexamethasone in patients with relapsed or refractory myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  17. Comorbidity in Older Patients Hospitalized with Cancer in Northeast China based on Hospital Discharge Data.International journal of environmental research and public health · 2020
    Article
  18. Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Dana Drzayich Antol, Louisville, Kentucky, USA. ddrzayichjankus@humana.com.
Adrianne Waldman Casebeer, Louisville, Kentucky, USA.
Raya Khoury, South San Francisco, California, USA.
Todd Michael, South San Francisco, California, USA.
Andrew RendaHumana Inc, Louisville, Kentucky, USA.
Sari Hopson, Louisville, Kentucky, USA.
Aparna Parikh, South San Francisco, California, USA.
Alisha Stein, Louisville, Kentucky, USA.
Mary Costantino, Louisville, Kentucky, USA.
Stephen Stemkowski, Louisville, Kentucky, USA.
Mikele Bunce, South San Francisco, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have demonstrated that comorbidities compound the adverse influence of cancer on health-related quality of life (HRQoL). Comorbidities adversely impact adherence to cancer treatment. Additionally, adherence to medications for comorbidities is positively associated with HRQoL for various diseases. This study used the Center for Disease Control and Prevention's Healthy Days measure of HRQoL to explore the association between HRQoL and adherence to comorbidity medication for elderly patients with cancer and at least one comorbid condition.

methodsWe conducted a cross-sectional survey combined with retrospective claims data. Patients with metastatic breast, lung or colorectal cancer were surveyed regarding their HRQoL, comorbidity medication adherence and cancer-related symptoms. Patients reported the number of physical, mental and total unhealthy days in the prior month. The Morisky Medication Adherence 8-point scale was differentiated into moderate/high (> 6) and low (≤ 6) comorbidity medication adherence.

resultsOf the 1847 respondents, the mean age was 69.2 years, most were female (66.8%) and the majority of the sample had Medicare coverage (88.2%). Low comorbidity medication adherence was associated with significantly more total, mental and physical unhealthy days. Low comorbidity medication adherence was associated with the presence of patient-reported cancer-related symptoms. Patients reporting low, as compared to moderate/high, comorbidity medication adherence had 23.4% more unhealthy days in adjusted analysis,

conclusionThe positive association between low comorbidity medication adherence and the number of unhealthy days suggests that addressing barriers to comorbidity medication adherence during cancer treatment may be an avenue for improving or maintaining HRQoL for older patients with cancer and comorbid conditions.

Indexed as

CancerComorbiditiesHealth-related quality of lifeHealthy daysMedication adherence

Identifiers

PMID30294709
PMCPMC6091619

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.