Evidence map›Paper›PMID 30294663›Full record

ArticleEJNMMI radiopharmacy and chemistry2018

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([

Joost Verbeek, Jonas Eriksson, Stina Syvänen, Marc Huisman, Robert C Schuit, Carla F M Molthoff, Rob A Voskuyl, Elizabeth C de Lange, Adriaan A Lammertsma, Albert D Windhorst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Evaluation of [Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Joost Verbeek1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Jonas Eriksson1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Stina Syvänen2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
Marc Huisman1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Robert C Schuit1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Carla F M Molthoff1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Rob A Voskuyl2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
Elizabeth C de Lange2Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
Adriaan A Lammertsma1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Albert D Windhorst1Department of Radiology & Nuclear Medicine, VU University Medical Center, P.O. box 7057, 1007 MB Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLLeiden University · NLUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2-(5-fluoro-2-oxoindolin-3-ylidene)-

results[

conclusionIn conclusion, [

Indexed as

[18F]4FIMPTC[18F]-fluorisatinP-glycoproteinP-gp inhibitorRadiofluorination

Identifiers

PMID30294663
PMCPMC6150866
OpenAlexW2891972648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.