Evidence map›Paper›PMID 30294653›Full record

ReviewCellular and molecular gastroenterology and hepatology2018

Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis.

Octavia Pickett-Blakely, Kimberly Young, Rotonya M Carr

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cellular and molecular gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04834063 (Evaluation of Serum Selenium and Zinc Levels in Non-alcoholic Fatty Liver Disease Patients), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04834063 completednot on this mapstarted 2021, after this paper: background citation

Evaluation of Serum Selenium and Zinc Levels in Non-alcoholic Fatty Liver Disease Patients

TypeobservationalSponsorSohag UniversityRan2021 to 2021Enrolled80ConditionsNAFLDArmsSerum Zinc a level, serum selenium level, Fibroscan measurement
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
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  10. Will a "multivitamin" a day keep the "MASLD doctor" away?Metabolism and target organ damage · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Octavia Pickett-BlakelyDivision of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Kimberly YoungDivision of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Rotonya M CarrDivision of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
Molecular Mechanisms Of Post-Transplant Recurrent Alcoholic Liver DiseaseR01AA026302 · NIAAA · UNIVERSITY OF WASHINGTON · PI ROTONYA M CARR · 2017 to 2026
$3.2M
The pathogenesis of insulin resistance in alcoholic liver diseaseK08AA021424 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI CARR, ROTONYA M · 2013 to 2017
$918k
NIAAA NIH HHS K08 AA021424NIAAA NIH HHS R01 AA026302NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Micronutrients include electrolytes, minerals, vitamins, and carotenoids, and are required in microgram or milligram quantities for cellular metabolism. The liver plays an important role in micronutrient metabolism and this metabolism often is altered in chronic liver diseases. Here, we review how the liver contributes to micronutrient metabolism; how impaired micronutrient metabolism may be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a systemic disorder of energy, glucose, and lipid homeostasis; and how insights gained from micronutrient biology have informed NAFLD therapeutics. Finally, we highlight some of the challenges and opportunities that remain with investigating the contribution of micronutrients to NAFLD pathology and suggest strategies to incorporate our understanding into the care of NAFLD patients.

Indexed as

HumansLiverMicronutrientsModels, BiologicalMolecular Targeted TherapyNon-alcoholic Fatty Liver DiseaseMicronutrientsALT, alanine aminotransferaseBMI, body mass indexcarotenoidsFXR, farnesoid X receptorIL, interleukinMicronutrientsmineralsNAFLDNAFLD, nonalcoholic fatty liver diseaseNASH, nonalcoholic steatohepatitisObesityROS, reactive oxygen speciesTGF, transforming growth factorVitamins

Identifiers

PMID30294653
PMCPMC6170520
OpenAlexW2888743683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.