Evidence map›Paper›PMID 30294639›Full record

ArticleData in brief2018

Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity.

Yasushi Kishimoto, Ikuko Tsukamoto, Atsuko Nishigawa, Akiko Nishimoto, Yutaka Kirino, Yoshihisa Kato, Ryoji Konishi, Tokumi Maruyama, Norikazu Sakakibara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yasushi KishimotoKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Ikuko TsukamotoDepartment of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Japan.
Atsuko NishigawaKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Akiko NishimotoKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Yutaka KirinoKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Yoshihisa KatoKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Ryoji KonishiDepartment of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Japan.
Tokumi MaruyamaKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Norikazu SakakibaraKagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Tokushima Bunri University · JPKagawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-Cl did not change the spontaneous activities and cognitive ability in the wild-type mice.

Indexed as

AD, Alzheimer׳s diseaseAlzheimer׳s diseaseAngiogenesisAPP, amyloid precursor proteinMWM, Morris water mazeNon-spatial memoryNovel object cognition testPS2, presenilin 2Spatial memorySpontaneous physical activity

Identifiers

PMID30294639
PMCPMC6168792
OpenAlexW2890750748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.