ArticleBone & joint research2018
Is patellofemoral pain a precursor to osteoarthritis?: Patellofemoral osteoarthritis and patellofemoral pain patients share aberrant patellar shape compared with healthy controls.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tibial tubercle transfer leads to clinically relevant improvement in patients with patellar maltracking without instability: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Inflammatory, angiogenic and neurogenic serum biomarkers in patients with patellofemoral pain compared to healthy controls.Osteoarthritis and cartilage open · 2026Article
- Pain-related function, muscle stiffness, and muscle activation in adults with patellofemoral pain.BMC musculoskeletal disorders · 2026Article
- Systematic review and meta-analysis of implant-specific outcomes in inlay and onlay patellofemoral arthroplasty for isolated patellofemoral osteoarthritis.Journal of experimental orthopaedics · 2025Review
- Increased Degenerative Biomarkers in Females with Patellofemoral Pain: A Cross-Sectional Analysis with 6-Month Progression.Diseases (Basel, Switzerland) · 2025Article
- Comparison of Inflammatory Biomarkers in Females with and Without Patellofemoral Pain and Associations with Patella Position, Hip and Knee Kinematics, and Pain.Biomedicines · 2025Article
- Classification approaches used to grade radiographic patellofemoral osteoarthritis: A scoping review.Osteoarthritis imaging · 2025Article
- Pain Decrement Using Radiofrequency Therapy After Knee Platelet-Rich Plasma Injections Within First 72 h in Active Populations with Patellar Chondropathy.Journal of clinical medicine · 2025Article
- Management of persistent patellofemoral pain conditions using a tricompartmental offloading knee brace: a case series.The Journal of the Canadian Chiropractic Association · 2024Article
- Effects of TJournal of magnetic resonance imaging : JMRI · 2024Article
- Article
- Is muscle activation diverse in females with isolated patellofemoral osteoarthritis contrasted with age-matched healthy controls during stair descent task?Frontiers in physiology · 2024Article
- Global research trends and hotspots in patellofemoral pain syndrome from 2000 to 2023: a bibliometric and visualization study.Frontiers in medicine · 2024Article
- Is the Akagi Line a Reliable Landmark for Adjusting the Rotational Axis of the Tibial Component in Patients with Patellofemoral Instability?Indian journal of orthopaedics · 2023Article
- Overweight and obesity in young adults with patellofemoral pain: Impact on functional capacity and strength.Journal of sport and health science · 2023Article
- Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort.PloS one · 2023Article
- Microstructural changes of cartilage and subchondral bone in a guinea pig model of early- and middle-stage patellofemoral arthritis.American journal of translational research · 2023Article
- The effect of biomechanical foot-based interventions on patellofemoral joint loads during gait in adults with and without patellofemoral pain or osteoarthritis: a systematic review protocol.Journal of foot and ankle research · 2022Article
- Patellofemoral kinematics in patellofemoral pain syndrome: The influence of demographic factors.Journal of biomechanics · 2022Article
- Patellofemoral joint degeneration: A review of current management.Journal of clinical orthopaedics and trauma · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIt has been hypothesized that patellofemoral pain, a common knee condition in adolescents and young adults, may be a precursor of degenerative joint changes and may ultimately lead to patellofemoral osteoarthritis. Since both conditions share several mechanical disease characteristics, such as altered contact area between the femur and patella and increased joint stress, we investigated whether these conditions share similar and different shape characteristics of the patella compared with normal controls.
methodsThis cross-sectional study compared three different study populations: 32 patellofemoral pain subjects (mean age, 32 years (22 to 45); 72% female); 56 isolated radiological patellofemoral osteoarthritis subjects (mean age, 54 years (44 to 58); 89% female); and 80 healthy control subjects (mean age, 52 years (44 to 58); 74% female). Measurements included questionnaires, and lateral and skyline radiographs of the knee. Two separate 30-point 2D statistical shape models of the patella were created from the lateral and skyline radiographs. A general linear model was used to test for differences in standardized shape modes (a specific shape variant of the patella) between patellofemoral osteoarthritis, patellofemoral pain, and controls, using Bonferroni correction and adjustment for body mass index and gender.
resultsFive shape modes showed statistically significant differences between groups: skyline modes 1 (p < 0.001), 8 (p = 0.004), and 10 (p < 0.001); and lateral modes 5 (p = 0.002) and 7 (p = 0.002). Skyline mode 8 and lateral mode 5 were similar for patellofemoral osteoarthritis and patellofemoral pain populations, while being statistically significant different from the control group.
conclusionOur results indicate that patellofemoral pain and patellofemoral osteoarthritis share similar shape characteristics, which are different from control subjects. These findings support the proposed continuum disease model of patellofemoral pain predisposing to the development of patellofemoral osteoarthritis.
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