ArticleEuropean geriatric medicine2018
Clinical factors increasing discrepancies of renal function assessment with MDRD and Cockcroft-Gault equations in old individuals.
Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Comparison of Different Hydration Strategies in Patients with Very Low-Risk Profiles of Contrast-Induced Nephropathy.Medical science monitor : international medical journal of experimental and clinical research · 2021Trial
- A Comparative Study on the Efficacy Between Cystatin C and Creatinine-Based Equations for Early Detection of Renal Damage in Patients of Eastern India.Indian journal of clinical biochemistry : IJCB · 2024Article
- A synergistic effect of variability in estimated glomerular filtration rate with chronic kidney disease on all-cause mortality prediction in patients with type 2 diabetes: a retrospective cohort study.Cardiovascular diabetology · 2021Observational
- Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database.BMC geriatrics · 2019Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractIn a daily clinical practice, glomerular filtration rate (GFR) is still estimated on the basis of short MDRD formula, whereas medications' Summaries of Product Characteristics suggest that GFR used for the dosage adjustment should be estimated based on the Cockcroft-Gault (C-G) equation. The aim of the study was to compare eGFR values calculated on the basis of short and full MDRD and C-G equations in PolSenior study participants with decreased eGFR.
methodsWe have assessed differences in the estimation of GFR between short and full MDRD, as well as C-G formula, all equations utilizing non-isotope-dilution mass spectrometry-calibrated measurements of serum creatinine, in the community-based population of 760 persons aged 65 years or above (mean age 82 ± 8 years) with estimated GFR < 60 ml/min/1.73 m
resultsThe better concordance, precision, and accuracy with MDRD short formula were found for MDRD
conclusionsIn very old subjects, especially females, dependent patients and those with visceral obesity, estimation of GFR based on short MDRD formula should not be used interchangeably with Cockcroft-Gault equation for the medicines dose tailoring.
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