Evidence map›Paper›PMID 30294251›Full record

ArticleFrontiers in neuroscience2018

Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment.

Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Irena Nalepa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Boosting Neurogenesis as a Strategy in Treating Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Astrocyte Intracellular CaNeurotoxicity research · 2021
    Article
  10. Article
  11. The Hallucinogenic SerotoninFrontiers in molecular neuroscience · 2021
    Article
  12. Article
  13. Chronic Fluoxetine Impairs the Effects of 5-HTFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katarzyna Rafa-ZabłockaDepartment of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Grzegorz KreinerDepartment of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Monika BagińskaDepartment of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Irena NalepaDepartment of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Polish Academy of Sciences · PLMaj Institute of Pharmacology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophic factors are regarded as crucial regulatory components in neuronal plasticity and are postulated to play an important role in depression pathology. The abundant expression of brain-derived neurotrophic factor (BDNF) in various brain structures seems to be of particular interest in this context, as downregulation of BDNF is postulated to be correlated with depression and its upregulation is often observed after chronic treatment with common antidepressants. It is well-known that BDNF expression is regulated by cyclic AMP response element-binding protein (CREB). In our previous study using mice lacking CREB in serotonergic neurons (Creb1

Indexed as

BDNFCREBCREMfluoxetineNGFNTF3serotonergic system

Identifiers

PMID30294251
PMCPMC6158386
OpenAlexW2892348319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.