ArticleNeuron2018
Neural Coding of Leg Proprioception in Drosophila.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 142 citations in OpenAlex.
- Sticking the landing: leg mechanosensory feedback coordinates the transition from flight to landing.bioRxiv : the preprint server for biology · 2026Article
- Dynamic vibration-driven feedback shapes predator-prey interactions in an orb-weaving spider.PLoS computational biology · 2026Article
- Nighttime sleep promotes mechanosensory habituation inbioRxiv : the preprint server for biology · 2026Article
- A spiking neural network model for fractional proprioceptive encoding of limb posture and movement in insects.Biological cybernetics · 2026Article
- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Noise enhances odor source localization.ArXiv · 2026Article
- Encoding of movement primitives and body posture through distributed proprioception in walking and climbing insects.Biological cybernetics · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
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- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- Foot placement control underlies stable locomotion across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.Nature communications · 2025Article
- Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking.bioRxiv : the preprint server for biology · 2025Article
- Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila.Current biology : CB · 2024Article
- Article
- Molecular regulation of axon termination in mechanosensory neurons.Development (Cambridge, England) · 2024Review
- Article
- Presynaptic inhibition selectively suppresses leg proprioception in behavingbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animals rely on an internal sense of body position and movement to effectively control motor behavior. This sense of proprioception is mediated by diverse populations of mechanosensory neurons distributed throughout the body. Here, we investigate neural coding of leg proprioception in Drosophila, using in vivo two-photon calcium imaging of proprioceptive sensory neurons during controlled movements of the fly tibia. We found that the axons of leg proprioceptors are organized into distinct functional projections that contain topographic representations of specific kinematic features. Using subclass-specific genetic driver lines, we show that one group of axons encodes tibia position (flexion/extension), another encodes movement direction, and a third encodes bidirectional movement and vibration frequency. Overall, our findings reveal how proprioceptive stimuli from a single leg joint are encoded by a diverse population of sensory neurons, and provide a framework for understanding how proprioceptive feedback signals are used by motor circuits to coordinate the body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.