Evidence map›Paper›PMID 30293686›Full record

SynthesisClinical psychology review2019

Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application.

Lalitha Iyadurai, Renée M Visser, Alex Lau-Zhu, Kate Porcheret, Antje Horsch, Emily A Holmes, Ella L James

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical psychology review, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03950869 (The Role of Expectations in the Development of Intrusive Memories), which is not on this map. Cited by 94 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03950869 nacompletednot on this map

The Role of Expectations in the Development of Intrusive Memories: An Experimental Approach Using the Trauma Film Paradigm

TypeinterventionalSponsorPhilipps University MarburgRan2019 to 2019Enrolled90ConditionsPosttraumatic Stress DisorderArmsPositive Expectation Manipulation, Negative Expectation Manipulation
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lalitha IyaduraiUniversity of Oxford, Department of Psychiatry, Oxford, UK. Electronic address: lalitha.iyadurai@psych.ox.ac.uk.
Renée M VisserMRC Cognition and Brain Sciences Unit, University of Cambridge, UK; University of Amsterdam, Department of Psychology, Amsterdam, The Netherlands.
Alex Lau-ZhuMRC Cognition and Brain Sciences Unit, University of Cambridge, UK; Kings College London, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, London, UK.
Kate PorcheretUniversity of Oxford, Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, Oxford, UK.
Antje HorschLausanne University Hospital, Woman-Mother-Child Department, Lausanne, Switzerland; Institute of Higher Education and Research in Healthcare, University of Lausanne, Lausanne University Hospital, Lausanne, Switzerland.
Emily A HolmesKarolinska Institutet, Division of Psychology, Department of Clinical Neuroscience, Stockholm, Sweden.
Ella L JamesMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.

Funding

Medical Research Council SUAG/013/RG91365Wellcome Trust 098461/Z/12/Z
6 · The paper itself

Abstract

Intrusive memories of a traumatic event can be distressing and disruptive, and comprise a core clinical feature of post-traumatic stress disorder (PTSD). Intrusive memories involve mental imagery-based impressions that intrude into mind involuntarily, and are emotional. Here we consider how recent advances in cognitive science have fueled our understanding of the development and possible treatment of intrusive memories of trauma. We conducted a systematic literature search in PubMed, selecting articles published from 2008 to 2018 that used the terms "trauma" AND ("intrusive memories" OR "involuntary memories") in their abstract or title. First, we discuss studies that investigated internal (neural, hormonal, psychophysiological, and cognitive) processes that contribute to intrusive memory development. Second, we discuss studies that targeted these processes using behavioural/pharmacological interventions to reduce intrusive memories. Third, we consider possible clinical implications of this work and highlight some emerging research avenues for treatment and prevention, supplemented by new data to examine some unanswered questions. In conclusion, we raise the possibility that intrusive memories comprise an alternative, possibly more focused, target in translational research endeavours, rather than only targeting overall symptoms of disorders such as PTSD. If so, relatively simple approaches could help to address the need for easy-to-deliver, widely-scalable trauma interventions.

Indexed as

Cognitive ScienceMemory, EpisodicHumansMental RecallPsychological TraumaStress Disorders, Post-TraumaticCognitive scienceIntrusive memoryMental imageryPost-traumatic stress disorderPsychological traumaTreatment innovation

Identifiers

PMID30293686
PMCPMC6475651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.