Evidence map›Paper›PMID 30293651›Full record

SynthesisThe American journal of cardiology2018

Meta-analysis of Prevalence and Risk Factors for Delirium After Transcatheter Aortic Valve Implantation.

Erica Tilley, Peter J Psaltis, Tobias Loetscher, Daniel H Davis, Stephanie L Harrison, Susan Kim, Hannah A D Keage

Open access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  3. Investigating how electroencephalogram measures associate with delirium: A systematic review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Pooled it
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  6. Trial
  7. Delirium Among Adults Undergoing Transcatheter Structural Heart Intervention: Incidence, Risk, and Clinical Phenotypes.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  8. Review
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Erica TilleyCognitive Ageing and Impairment Neurosciences Lab, University of South Australia, Adelaide, South Australia, Australia. Electronic address: erica.tilley@mymail.unisa.edu.au.
Peter J PsaltisSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Vascular Research Centre, Heart Health Theme, South Australian Health and Medical Research Institute, SAHMRI, Adelaide, South Australia, Australia.
Tobias LoetscherCognitive Ageing and Impairment Neurosciences Lab, University of South Australia, Adelaide, South Australia, Australia.
Daniel H DavisMRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Stephanie L HarrisonDepartment of Rehabilitation, Aged and Extended Care, Flinders University, Adelaide, South Australia, Australia.
Susan KimVascular Research Centre, Heart Health Theme, South Australian Health and Medical Research Institute, SAHMRI, Adelaide, South Australia, Australia; Flinders Centre for Epidemiology and Biostatistics, College of Medicine and Public Health, Flinders University.
Hannah A D KeageCognitive Ageing and Impairment Neurosciences Lab, University of South Australia, Adelaide, South Australia, Australia.
University of South Australia · AUFlinders University · AUMRC Unit for Lifelong Health and Ageing · GBSouth Australian Health and Medical Research Institute · AU

Funding

Medical Research Council MC_UU_12019/1Wellcome Trust 107467/Z/15/Z
6 · The paper itself

Abstract

Delirium is a severe and common complication following transcatheter aortic valve implantation (TAVI). We sought to identify the prevalence and risk factors associated with the development of postprocedural delirium in patients aged over 60 years who underwent elective TAVI for aortic stenosis. Overall, 1,051 articles were searched, from which 9 studies were included. The prevalence of delirium following TAVI was higher in studies that assessed delirium for a minimum of 3 consecutive days (24.9%) compared with the studies that did not (2%). There were large effect sizes (d > 0.8) for 3 risk factors: acute kidney injury (odds ratio [OR] 5, p < 0.001), transapical approach (OR 4, p < 0.001) and carotid artery disease (OR 4, p < 0.001), whilst small effect sizes were found for a history of atrial fibrillation, prior stroke/transient ischemic attack, peripheral artery disease, hypertension, and prior cognitive impairment. In conclusion, 23% of patients 60 years and over who underwent TAVI experience delirium, a preventative cause of cognitive impairment and dementia. Recognition of risk factors for delirium after TAVI, such as a history of carotid artery disease, development of acute kidney injury, or use of a transapical approach, provides an opportunity to implement proven delirium preventative measures.

Indexed as

Risk AssessmentAortic Valve StenosisDeliriumGlobal HealthHumansPostoperative ComplicationsPrevalenceRisk FactorsTranscatheter Aortic Valve Replacement

Identifiers

PMID30293651
PMCPMC6269593
OpenAlexW2892052407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.