ReviewBiological psychiatry2019
Perinatal Nutrition and Programmed Risk for Neuropsychiatric Disorders: A Focus on Animal Models.
Review in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts.European child & adolescent psychiatry · 2022Pooled it
- Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors.BMJ mental health · 2026Article
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Animal models for the study of ADHD: the need for next-generation models.Frontiers in psychiatry · 2026Review
- Perinatal Western-style diet exposure associated with altered sensory functional connectivity in infant Japanese macaques.Physiological reports · 2025Article
- Reduced Availability of Essential Amino Acids Disrupts Differentiation of Anorexigenic POMC Neurons in the Fetal Rat Hypothalamus.Molecular neurobiology · 2025Article
- Differential Epigenetic Regulation of Glutamatergic Synapse Pathway in Adults With Prenatal Exposure to Famine.The European journal of neuroscience · 2025Article
- Construction and validation of a risk prediction model for hypoglycemia in patients with gestational diabetes mellitus.BMC pregnancy and childbirth · 2025Article
- Fundamental origins of neural tube defects with a basis in genetics and nutrition.Experimental brain research · 2025Review
- Dietary glycemic index and load during pregnancy and offspring behavioral outcomes: exploring sex differences.European journal of pediatrics · 2025Observational
- Standardized pipelines support and facilitate integration of diverse datasets at the Rat Genome Database.Database : the journal of biological databases and curation · 2025Article
- Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review.Life (Basel, Switzerland) · 2024Review
- Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota.Nutrients · 2024Review
- Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.Scientific reports · 2024Article
- Article
- Perinatal high-fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits controlling gastric motility.The Journal of physiology · 2023Article
- Editorial: The role of early-life nutrition and metabolism in brain development and adult behavior.Frontiers in neuroscience · 2023Article
- Review
- Perception of the Body Image in Women after Childbirth and the Specific Determinants of Their Eating Behavior: Cross-Sectional Study (Silesia, Poland).International journal of environmental research and public health · 2022Article
- Maternal diet and obesity shape offspring central and peripheral inflammatory outcomes in juvenile non-human primates.Brain, behavior, and immunity · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Maternal nutrition is critically important for fetal development. Recent human studies demonstrate a strong connection between diet during pregnancy and offspring risk for neuropsychiatric disorders including depression, anxiety, and attention-deficit/hyperactivity disorder. Animal models have emerged as a crucial tool for understanding maternal nutrition's contribution to prenatal programming and the later development of neuropsychiatric disorders. This review highlights preclinical studies examining how maternal consumption of the three macronutrients (protein, fats, and carbohydrates) influence offspring negative-valence behaviors relevant to neuropsychiatric disorders. We highlight the translational aspects of animal models and so examine exposure periods that mirror the neurodevelopmental stages of human gestation. Because of our emphasis on programmed changes in neurobehavioral development, studies that continue diet exposure until assessment in adulthood are not discussed. The presented research provides a strong foundation of preclinical evidence of nutritional programming of neurobehavioral impairments. Alterations in risk assessment and response were observed alongside neurodevelopmental impairments related to neurogenesis, synaptogenesis, and synaptic plasticity. To date, the large majority of studies utilized rodent models, and the field could benefit from additional study of large-animal models. Additional future directions are discussed, including the need for further studies examining how sex as a biological variable affects the contribution of maternal nutrition to prenatal programming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.