Evidence map›Paper›PMID 30293536›Full record

ArticleEpidemiology and infection2018

The changing epidemiology worldwide of

D P O'Brien, I Jeanne, K Blasdell, M Avumegah, E Athan

Abstract read
In one paragraph

Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Case reports in infectious diseases · 2026
    Article
  5. Article
  6. Buruli ulcer.Nature reviews. Disease primers · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Life (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Emergence and spread ofMicrobiology spectrum · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

D P O'BrienGeelong Centre for Emerging Infectious Diseases, Geelong, Australia.ORCID https://orcid.org/0000-0001-5418-3330
I JeanneSchool of Medicine, Deakin University, Geelong, Australia.
K BlasdellCSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, Australia.
M AvumegahGeelong Centre for Emerging Infectious Diseases, Geelong, Australia.
E AthanGeelong Centre for Emerging Infectious Diseases, Geelong, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium ulcerans is recognised as the third most common mycobacterial infection worldwide. It causes necrotising infections of skin and soft tissue and is classified as a neglected tropical disease by the World Health Organization (WHO). However, despite extensive research, the environmental reservoir of the organism and mode of transmission of the infection to humans remain unknown. This limits the ability to design and implement public health interventions to effectively and consistently prevent the spread and reduce the incidence of this disease. In recent years, the epidemiology of the disease has changed. In most endemic regions of the world, the number of cases reported to the WHO are reducing, with a 64% reduction in cases reported worldwide in the last 9 years. Conversely, in a smaller number of countries including Australia and Nigeria, reported cases are increasing at a rapid rate, new endemic areas continue to appear, and in Australia cases are becoming more severe. The reasons for this changing epidemiology are unknown. We review the epidemiology of M. ulcerans disease worldwide, and document recent changes. We also outline and discuss the current state of knowledge on the ecology of M. ulcerans, possible transmission mechanisms to humans and what may be enabling the spread of M. ulcerans into new endemic areas.

Indexed as

Buruli ulcerepidemiologyMycobacterium ulceransspreadtransmission

Identifiers

PMID30293536
PMCPMC6518549

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.