Evidence map›Paper›PMID 30293229›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2019

Anti-tumor effect of endostatin in a sleep-apnea mouse model with tumor.

X-B Zhang, Y-Y Yang, Y Zeng, H-Q Zeng, B-B Fu, C-Y Ko, X Luo, Y-P Du, L-D Chen, Y-T Lai and 1 more

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Cancer and obstructive sleep apnea.Chinese medical journal · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. The association between obstructive sleep apnea and lung nodule, carcinoembryonic antigen.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Collagen at the maternal-fetal interface in human pregnancy.International journal of biological sciences · 2020
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

X-B ZhangDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.ORCID http://orcid.org/0000-0002-5155-8560
Y-Y YangDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
Y ZengSecond Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China. ymzeng08@163.com.
H-Q ZengDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China. zhq20071212@xmu.edu.cn.
B-B FuDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
C-Y KoSecond Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
X LuoDepartment of Computer Science, Xiamen University, Xiamen, 361005, China.
Y-P DuDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
L-D ChenDepartment of Respiratory Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Xiangcheng District, Zhangzhou, China.
Y-T LaiDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
Y WuDepartment of Respiratory Medicine, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
Fujian Medical University · CNXiamen University · CN

Funding

Fujian Provincial Department of Science and Technology 2018-2-65Natural Science Foundation of Fujian Province 2018J01393Xiamen Science and Technology Bureau 3502Z20154019
6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) is associated with cancer incidence and mortality. The underlying mechanism is unclear. This study aims to evaluate the influence of intermittent hypoxia (IH), a novel hallmark of OSA, on tumor and to access the anti-tumor effect of endostatin on a mouse model with OSA.

methodsThe C57BL/6 J mice were randomly classified into four groups: control (normoxia) (CTL), control plus endostatin (CTL + ED), IH, and IH plus endostatin (IH + ED). Mice in IH and IH + ED groups were subjected to IH 8 h per day in 5 weeks. Lewis lung cancer cells were injected into the flank of each mouse after 1 week of IH exposure. Endostatin was also intraperitoneally injected after tumor volume reached about 200 mm

resultsMice had higher SUVmax in the IH group than the CTL group (p < 0.01). When compared with mice in the CTL group, those in the IH group had significantly greater MVD values (p < 0.001). The SUVmax can be attenuated by endostatin both in the CTL (p < 0.01) and IH conditions (p < 0.001). When compared with CTL group, mice in the IH group had increased MVD values (p < 0.001) and VEGF expression both at mRNA (p < 0.05) and protein levels (p < 0.001 in western blotting results). Treatment with endostatin attenuated serum and tissue VEGF levels, lowering the MVD values. As compared to normoxia condition, the endostatin-therapeutic effects were more significant under the IH condition (p < 0.05 in western blotting results).

conclusionsMicro-PET-CT imaging is a promising non-invasive technique to evaluate the tumor metabolic characteristics under IH condition in vivo. The anti-tumor effect of endostatin under IH condition is superior to that of the normoxia condition.

Indexed as

Disease Models, AnimalAnimalsAntineoplastic AgentsCarcinoma, Lewis LungEndostatinsHypoxiaMaleMiceMice, Inbred C57BLSleep Apnea, ObstructiveTumor Cells, CulturedAntineoplastic AgentsEndostatinsEndostatinIntermittent hypoxiaPositron emission tomographySleep apneaTumor

Identifiers

PMID30293229
OpenAlexW2895577486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.