ArticleAnnals of nuclear medicine2019
PET imaging of noradrenaline transporters in Parkinson's disease: focus on scan time.
Article in Annals of nuclear medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Towards a Biologically Defined Diagnosis: Incorporating Pathophysiological Measures Into Parkinson's Disease Clinical Criteria.Parkinson's disease · 2026Review
- The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease.Neurobiology of disease · 2023Article
- Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function.Frontiers in aging neuroscience · 2023Article
- Associations among locus coeruleus catecholamines, tau pathology, and memory in aging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- The Design and Application of an Appropriate Parkinson's Disease Animal Model in Regenerative Medicine.Advances in experimental medicine and biology · 2021Review
- Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases.Cells · 2020Review
- Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia.International journal of molecular sciences · 2020Review
- Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn subjects with idiopathic Parkinson's disease (PD) the functional state of the locus coeruleus and the subtle derangements in the finely tuned dopamine-noradrenaline interplay are largely unknown. The PET ligand (S,S)-[
methodsTen patients with idiopathic PD underwent dynamic C-11 MRB PET (120 min duration) and brain magnetic resonance imaging. Model-based (i.e., simplified and multilinear reference tissue model 2) non-displaceable binding potentials (BP) of selected brain regions were analyzed for a 90 min scan protocol and compared with BP derived from static 30-min data with different starting times (30, 40, 50 and 60 min) after C-11 MRB injection. Intraclass correlation coefficient and linear regression analysis were used to explore the association between BP of different scan durations. Spearman's ρ served to describe the correlation of BP with demographic and clinical parameters.
resultsWith respect to kinetic models, BP
conclusionsAn acquisition time of 30 min, starting 50 or 60 min after C-11 MRB injection, allows a reliable estimation of noradrenaline transporter binding values in Parkinsonian people. A short acquisition time can significantly reduce the discomfort of Parkinsonian patients and facilitate PET studies, especially in the medication-off-state.
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