ReviewApplied microbiology and biotechnology2018
Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei.
Review in Applied microbiology and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
261 citing papers in PubMed, 342 citations in OpenAlex.
- Fungi and mycotoxins during conventional and improved postharvest processing and storage of local rice in Nigeria.Mycotoxin research · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase, pectinesterase, pectin lyase and arabinan endo-1,5-α-l-arabinanase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme cellulase from the genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing leucyl aminopeptidase and Xaa-Pro dipeptidyl-peptidase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme oryzin from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme aspergillopepsin I from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing carboxypeptidase C, oryzin and leucyl aminopeptidase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Applications of Fungi and Fungal-Derived Ingredients in the QPS and GRAS Systems.Journal of microbiology and biotechnology · 2026Review
- Filamentous multiscale characterization of the cultivation of Actinomadura namibiensis pellets for model-based prediction of labyrinthopeptin A1 biosynthesis.Microbial cell factories · 2026Article
- Integrated bioprocess optimization of cellulase and xylanase production by Penicillium argillaceum using lignocellulosic agro-industrial residues.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing arabinan endo-1,5-α-l-arabinanase and endo-polygalacturonase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme pectinesterase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme endo-polygalacturonase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme mannan endo-1,4-β-mannosidase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase and pectinesterase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme pectin lyase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme pectin lyase from the genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme glucan 1,4-α-glucosidase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
201 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review presents an update on the current knowledge of the secondary metabolite potential of the major fungal species used in industrial biotechnology, i.e., Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei. These species have a long history of safe use for enzyme production. Like most microorganisms that exist in a challenging environment in nature, these fungi can produce a large variety and number of secondary metabolites. Many of these compounds present several properties that make them attractive for different industrial and medical applications. A description of all known secondary metabolites produced by these species is presented here. Mycotoxins are a very limited group of secondary metabolites that can be produced by fungi and that pose health hazards in humans and other vertebrates when ingested in small amounts. Some mycotoxins are species-specific. Here, we present scientific basis for (1) the definition of mycotoxins including an update on their toxicity and (2) the clarity on misclassification of species and their mycotoxin potential reported in literature, e.g., A. oryzae has been wrongly reported as an aflatoxin producer, due to misclassification of Aspergillus flavus strains. It is therefore of paramount importance to accurately describe the mycotoxins that can potentially be produced by a fungal species that is to be used as a production organism and to ensure that production strains are not capable of producing mycotoxins during enzyme production. This review is intended as a reference paper for authorities, companies, and researchers dealing with secondary metabolite assessment, risk evaluation for food or feed enzyme production, or considerations on the use of these species as production hosts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.