ArticlePediatric radiology2019
Fetal brain morphometry on prenatal magnetic resonance imaging in congenital diaphragmatic hernia.
Article in Pediatric radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Fetal Cardiac Magnetic Resonance Imaging in Left-Sided Diaphragmatic Hernia.JACC. Case reports · 2025Article
- Subarachnoid Space Measurements in the Second Trimester Using MR Imaging.AJNR. American journal of neuroradiology · 2025Article
- Diffusion Tensor Imaging of Fetuses With Congenital Diaphragmatic Hernia.Prenatal diagnosis · 2025Article
- Increased risk of clinically relevant neurodevelopmental disorders in survivors of congenital diaphragmatic hernia: a population-based study.Pediatric surgery international · 2024Article
- The brain of fetuses with congenital diaphragmatic hernia shows signs of hypoxic injury with loss of progenitor cells, neurons, and oligodendrocytes.Scientific reports · 2024Article
- [Congenital diaphragmatic hernia : Imaging-from diagnosis to aftercare].Radiologie (Heidelberg, Germany) · 2024Article
- The role of point-of-care ultrasound in the management of neonates with congenital diaphragmatic hernia.Pediatric research · 2024Review
- Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging.Frontiers in neurology · 2024Article
- Anti-inflammatory effects of antenatal administration of stem cell derived extracellular vesicles in the brain of rat fetuses with congenital diaphragmatic hernia.Pediatric surgery international · 2023Article
- Beyond the diaphragm and the lung: a multisystem approach to understanding congenital diaphragmatic hernia.Pediatric surgery international · 2023Review
- Longitudinal MRI Evaluation of Brain Development in Fetuses with Congenital Diaphragmatic Hernia around the Time of Fetal Endotracheal Occlusion.AJNR. American journal of neuroradiology · 2023Article
- The Role of Fetal Brain Magnetic Resonance Imaging in Current Fetal Medicine.Journal of the Belgian Society of Radiology · 2022Article
- Pilot study of fetal brain development and morphometry in prenatal opioid exposure and smoking on fetal MRI.Journal of neuroradiology = Journal de neuroradiologie · 2022Article
- Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia.Brain sciences · 2021Article
- Bilateral Congenital Diaphragm Agenesis in a Neonate with Hydrocephalus: Case Report.European journal of radiology open · 2020Article
- Brain growth in fetuses with congenital diaphragmatic hernia.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany infants with congenital diaphragmatic hernia (CDH) show brain abnormality on postnatal brain MRI related to severity of CDH, degree of lung hypoplasia, intrathoracic liver, right diaphragmatic hernia and large diaphragmatic defect. It is not known whether these factors affect brain growth in utero in CDH.
objectiveTo assess prenatal brain morphometry and abnormalities on fetal MR in congenital diaphragmatic hernia. MATERIALS AND
methodsWe retrospectively reviewed 109 fetal MRIs in 63 fetuses with CDH from 2009 to 2014 (27 died before discharge, 36 survived to discharge). We compared brain injury and gestational-age-corrected z-scores of brain measurements between survivors and non-survivors. We assessed correlations between brain abnormalities and CDH severity.
resultsEnlarged extraaxial space was the most common abnormality, frequently seen on fetal MRI at >28 weeks of gestation, similar in survivors versus non-survivors. Anteroposterior cerebellar vermis dimension at >28 weeks of gestation was smaller in non-survivors compared to survivors (P=.02) and positively correlated with observed/expected total fetal lung volume (P=.01). Transverse cerebellar diameter at >28 weeks of gestation was also positively correlated with observed/expected total fetal lung volume (P=.04). We did not identify maturational delay, abnormal parenchymal signal or intracranial hemorrhage on fetal MRI.
conclusionEnlarged extraaxial spaces in the third trimester was the most common abnormality on fetal MRI in congenital diaphragmatic hernia. Cerebellar dimensions on fetal MRI are associated with CDH severity. There was no major brain parenchymal injury on fetal MRI, even in the third trimester, in CDH survivors and non-survivors.
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