Evidence map›Paper›PMID 30293136›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2018

Nuclear calcineurin is a sensor for detecting Ca

Silvana Olivares-Florez, Martin Czolbe, Fabian Riediger, Lea Seidlmayer, Tatjana Williams, Peter Nordbeck, Jörn Strasen, Cristina Glocker, Monique Jänsch, Petra Eder-Negrin and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. CaInflammation and regeneration · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  6. Review
  7. Article
  8. CaBiophysical journal · 2020
    Article
  9. Review
  10. Calcium Signaling in Cardiomyocyte Function.Cold Spring Harbor perspectives in biology · 2020
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Silvana Olivares-FlorezDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Martin CzolbeDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Fabian RiedigerDepartment of Cardiology, Nephrology and Pulmonology, Brandenburg Medical School, University Hospital Brandenburg, 14770, Brandenburg/Havel, Germany.ORCID 0000-0003-3425-8109
Lea SeidlmayerDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Tatjana WilliamsDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Peter NordbeckDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Jörn StrasenDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Cristina GlockerDepartment of Cardiology, Nephrology and Pulmonology, Brandenburg Medical School, University Hospital Brandenburg, 14770, Brandenburg/Havel, Germany.
Monique JänschDepartment of Cardiology, Nephrology and Pulmonology, Brandenburg Medical School, University Hospital Brandenburg, 14770, Brandenburg/Havel, Germany.
Petra Eder-NegrinDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Paula Arias-LozaDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Melanie MühlfelderDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany.
Jelena PlačkićInstitute of Pharmacology and Clinical Pharmacy, Philips-University Marburg, 35033, Marburg, Germany.
Katrin G HeinzeRudolf-Virchow-Center, Julius-Maximilians-University, 97080, Würzburg, Germany.
Jeffery D MolkentinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, University of Cincinnati, Cincinnati, OH, 20815, USA.
Stefan EngelhardtInstitute of Pharmacology and Toxicology, Technische Universität München, 80802, Munich, Germany.
Jens KockskämperInstitute of Pharmacology and Clinical Pharmacy, Philips-University Marburg, 35033, Marburg, Germany.
Oliver RitterDepartment of Internal Medicine I-Cardiology, University Hospital Würzburg, 97080, Würzburg, Germany. o.ritter@klinikum-brandenburg.de.
Universitätsklinikum Würzburg · DEUniversitätsklinikum Brandenburg an der Havel · DEPhilips (Germany) · DECincinnati Children's Hospital Medical Center · USGerman Centre for Cardiovascular Research · DEUniversity of Würzburg · DE

Funding

BMBF CHFC "heart failure" projects B2, C2BMBF VIP0014Deutsche Forschungsgemeinschaft (DE) Ri1085/4-1
6 · The paper itself

Abstract

In continuously beating cells like cardiac myocytes, there are rapid alterations of cytosolic Ca

Indexed as

Angiotensin IIAnimalsCalcineurinCalciumInositol 1,4,5-Trisphosphate ReceptorsMice, Inbred C57BLMyocardial ContractionMyocytes, CardiacNuclear EnvelopeRats, WistarAngiotensin IICalcineurinCalciumInositol 1,4,5-Trisphosphate ReceptorsIp3r2 protein, mouseCalcineurin/NFAT signalingHeart failureIP3R2 receptorMyocardial hypertrophyNuclear Ca2+

Identifiers

PMID30293136
OpenAlexW2895157940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.