SynthesisEuropean child & adolescent psychiatry2019
Suicidal behaviors and irritability in children and adolescents: a systematic review of the nature and mechanisms of the association.
Synthesis in European child & adolescent psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07603986 (CBT for Anger and Aggression in Children), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CBT for Anger and Aggression in Children: A Pilot Study of Irritability and Suicidality
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Factors Associated with Suicidal Behavior in Adolescents: An Umbrella Review Using the Socio-Ecological Model.Community mental health journal · 2025Pooled it
- Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Pharmacological intervention for irritability, aggression, and self-injury in autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2023Pooled it
- Foster Care Leads to Lower Irritability Among Adolescents with a History of Early Psychosocial Deprivation.Research on child and adolescent psychopathology · 2024Trial
- Parent training for the treatment of irritability in children and adolescents: a multisite randomized controlled, 3-parallel-group, evaluator-blinded, superiority trial.BMC psychology · 2022Trial
- Mood dynamics in adolescents and young adults with and without a history of suicidal thoughts and actions: a network approach.BMC psychiatry · 2026Article
- Clinical and Familial Predictors of Suicidal Ideation and Treatment Outcomes in Hospitalized Adolescents in Turkey: A Retrospective Analysis.Children (Basel, Switzerland) · 2026Article
- Youth Irritability as Consequence and Predictor of Family Conflict From Late Childhood to Early Adolescence.Child psychiatry and human development · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Suicide Risk in 8- to 12-Year-Old Children: Retrospective Review of Emergency Department Electronic Health Records.JAACAP open · 2026Article
- Family Accommodation of Pediatric Irritability: Development and Psychometric Properties of the Family Accommodation Scale for Irritability.Behavior therapy · 2026Article
- The relationship between irritability and suicidal ideation: the chain mediating effects of rumination and distress tolerance.BMC psychiatry · 2025Article
- Associations of childhood irritability and parenting profiles with youth suicide attempt: a longitudinal person-centered approach.Psychological medicine · 2025Article
- Examining harsh parenting as a moderator in the association between childhood irritability and adolescent suicidal behaviors.Psychological medicine · 2025Article
- The Presence of Externalizing Diagnoses Increases the Risk of Suicidal Thoughts and Behaviors in Youth Enriched for Early-Onset Depression.JAACAP open · 2025Article
- An In-Depth Exploration of the Relationship Between Suicidal Ideation and Emotion Processes in Adolescents.Behavior therapy · 2024Article
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
- Neurodevelopmental Disorders and Suicide: A Narrative Review.Journal of clinical medicine · 2024Review
- Unveiling Adolescent Suicidality: Holistic Analysis of Protective and Risk Factors Using Multiple Machine Learning Algorithms.Journal of youth and adolescence · 2024Article
- Suicidality risk in children and adolescents with externalizing disorders: symptoms profiles at high risk and the moderating role of dysregulated family relationships.European child & adolescent psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While many psychiatric disorders are associated with an increased risk for suicidal behaviors (SB) in children and adolescents, a few studies have explored the role of clinical symptoms based on a dimensional approach. Irritability is seen as a marker, a general psychopathology, and a symptom of both externalizing and internalizing disorders. In this review, we are interested in determining whether and how irritability can predict SB in youth. First, we reviewed consistencies and variation in the literature linking irritability to suicidal ideation (SI) and suicide attempt (SA). Second, based on the available models, we proposed specific mechanistic pathways, whereby irritability may modulate the risk for SB. Irritability has been found associated with SB both in cross-sectional and in longitudinal studies. The relation is consistent in different settings (i.e., general population and clinical settings) and across psychiatric disorders. The association is reduced but persists after adjusting for psychiatric disorder, including depression. On one hand, irritability constitutes a risk factor for SI via the onset of internalized disorder. On the other hand, irritable youth may be more prone to attempt suicide when experiencing SI. The measures for irritability were heterogeneous. A limited number of studies were designed to explore the role of mediators and/or moderators. Recognizing irritability in children and adolescents is a key issue with regards to suicide prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.