Evidence map›Paper›PMID 30293094›Full record

ReviewCurrent neurology and neuroscience reports2018

The Role of Tau Imaging in Parkinsonian Disorders.

Jochen Hammes, Alexander Drzezga, Thilo van Eimeren

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. "Parkinson's disease" on the way to progressive supranuclear palsy: a review on PSP-parkinsonism.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  5. Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  6. IntegratedFrontiers in aging neuroscience · 2021
    Article
  7. Review
  8. Article
  9. [Propofol combined with hypoxia induces cognitive dysfunction in immature ratsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jochen HammesMultimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany. jochen.hammes@uk-koeln.de.
Alexander DrzezgaMultimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
Thilo van EimerenMultimodal Neuroimaging Group, Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewDifferential diagnosis of atypical Parkinson syndromes (APS) is difficult as clinical presentations may vary and as there is a strong overlap between disease entities. Aggregations of misfolded and hyperphosphorylated tau proteins are the common denominator of many of these diseases. RECENT

findingsSeveral tau targeting positron emission tomography (PET) tracers have been evaluated as possible biomarkers in APS in the recent years. For Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration, promising results have been reported with regard to the ability to detect the presence of disease and to discriminate patients from controls. However, the discussion about the specificity of the first-generation radiotracers and their value in the clinical context is ongoing. A combined interpretation of signal strength and distribution pattern in PET scans with first- and second-generation tracers may be helpful in clinical diagnosis and follow-up of patients with APS.

Indexed as

Alzheimer DiseaseDiagnosis, DifferentialHumansParkinsonian DisordersPositron-Emission TomographySupranuclear Palsy, Progressivetau Proteinstau ProteinsAtypical Parkinson syndromesFlortaucipirPBB3Tau PETTHK-5351

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.