ArticleiScience2018
M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry.
Open access · goldAbstract read
In one paragraph
Article in iScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Neosaxitoxin Downregulates Inflammation in an Equine In Vivo Model of Osteoarthritis.Biomolecules · 2026Article
- Temporal immunomodulation of CD4Science advances · 2026Article
- Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1-STING Inflammatory Axis.Smart medicine · 2026Article
- Calcium Signaling in Macrophages During a Wound Response In Vivo.International journal of molecular sciences · 2026Article
- Article
- Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.PNAS nexus · 2026Article
- Orai1 acts as a novel CaExperimental & molecular medicine · 2026Article
- Modulation of macrophage survival duringFrontiers in cellular and infection microbiology · 2026Review
- Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages.International journal of molecular sciences · 2025Review
- Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality.iScience · 2025Article
- Barium titanate piezoelectric nanoparticles induce M1 polarization in mouse macrophages via ultrasound in vitro.Scientific reports · 2025Article
- Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability.bioRxiv : the preprint server for biology · 2025Article
- Metallic nanomedicine in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025Review
- Article
- Biosynthesized Calcium Peroxide Nanoparticles as a Multifunctional Platform for Liver Cancer Therapy.International journal of molecular sciences · 2025Article
- Article
- The Role of mtDNA Mutations in Atherosclerosis: The Influence of Mitochondrial Dysfunction on Macrophage Polarization.International journal of molecular sciences · 2025Review
- Tension at the gate: sensing mechanical forces at the blood-brain barrier in health and disease.Journal of neuroinflammation · 2024Review
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Arun ChauhanDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Yuyang SunDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Pramod SukumaranDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Fredice O Quenum ZangbedeDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Christopher N JondleDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Atul SharmaDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Dustin L EvansDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Pooja ChauhanDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Randolph E SzlabickDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Mary O AalandDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Lutz BirnbaumerNeurobiology Laboratory, NIHES, NIH, 111 TW Alexander Dr., Research Triangle Park, Durham, NC 27709, USA; School of Medical Sciences, Catholic University of Argentina, Institute of Biomedical Research (BIOMED UCA-CONICET), Av. Alicia Moreau de Justo 1300, Edificio San Jose Piso 3, Buenos Aires C1107AAZ, Argentina.
Jyotika SharmaDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Brij B SinghDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA.
Bibhuti B MishraDepartment of Biomedical Sciences and Department of Surgery, School of Medicine & Health Sciences, The University of North Dakota, 1301 N Columbia Road, Grand Forks, ND 58202, USA. Electronic address: bibhuti.mishra@med.und.edu.
University of North Dakota · USPontificia Universidad Católica Argentina · AR
Funding
Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Chris Jurgens · 2012 to 2026
$53.0MYersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BRADLEY, DAVID S. · 2016 to 2025
$19.9MTRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5MTransmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1MMolecular mechanism of Mincle mediated NET formation:Implications for pneumonic sepsisR01AI121804 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHARMA, JYOTIKA · 2016 to 2020
$2.0MEpigenetic regulations in Sjogern's syndromeR01DE022765 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2017 to 2021
$1.8MIdentification of protective proteins of Francisella using a novel comparative imR21AI107457 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI SHARMA, JYOTIKA · 2014 to 2015
$388kEfferocytosis and neutrophil homeostasis in pneumonic sepsisR21AI136472 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI SHARMA, JYOTIKA · 2018 to 2019
$382kGalectins as novel alarmins in salivary gland inflammationR21DE024300 · NIDCR · UNIVERSITY OF NORTH DAKOTA · PI MISHRA, BIBHUTI BHUSAN, SINGH, BRIJ B · 2015 to 2016
$382kIntramural NIH HHS Z01 ES101684NIAID NIH HHS R01 AI121804NIAID NIH HHS R21 AI107457NIAID NIH HHS R21 AI136472NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R01 DE022765NIDCR NIH HHS R21 DE024300NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123
Abstract
Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated Ca
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Biological SciencesImmune ResponseImmunology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.