ArticleJournal of affective disorders2019
Preliminary evidence of an association between increased cortical inhibition and reduced suicidal ideation in adolescents treated for major depression.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04502758 (A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.Translational psychiatry · 2025Pooled it
- A Systematic Review of Neuromodulation Treatment Effects on Suicidality.Frontiers in human neuroscience · 2021Pooled it
- A Systematic Review of Long-Interval Intracortical Inhibition as a Biomarker in Neuropsychiatric Disorders.Frontiers in psychiatry · 2021Pooled it
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression.Frontiers in psychiatry · 2024Article
- Association of In-School and Electronic Bullying with Suicidality and Feelings of Hopelessness among Adolescents in the United States.Children (Basel, Switzerland) · 2023Article
- Article
- Physiologically informed neuromodulation.Journal of the neurological sciences · 2022Article
- GABACurrent topics in behavioral neurosciences · 2022Article
- Journal of Affective Disorders Special Issue on Suicide-Related Research: Hopeful progress but much research urgently needed.Journal of affective disorders · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundSuicide is a leading cause of death among youth. Prior research using transcranial magnetic stimulation (TMS) has implicated deficits in GABAergic cortical inhibition in adolescent suicidal behavior, yet no studies have assessed whether cortical inhibition varies over time in conjunction with changes in suicidal ideation (SI). This study examined dynamic changes in long-interval intracortical inhibition (LICI), a TMS measure of GABA
methodsTen depressed adolescents (aged 13-17) underwent clinical assessment and TMS testing at baseline and again at follow-up. All were treated with antidepressant medication in the interim. SI was measured with the Columbia Suicide Severity Rating Scale (C-SSRS) Intensity of Ideation subscale. LICI was measured at interstimulus intervals of 100 and 150 ms.
resultsThere was a significant partial correlation, controlling for change in depression severity, between ΔLICI-100 and change in SI as measured by ΔC-SSRS (ρ = .746, df = 7, p = .021), which remained after also controlling for time to follow-up assessment (ρ = .752, df = 6, p = .032). No significant correlation was observed between ΔLICI-150 and change in SI. LIMITATIONS: Sample size; variable follow-up interval; inability to control for age, sex, and potential treatment effects.
conclusionsThese data offer preliminary signal of an association between increases in GABA
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