Evidence map›Paper›PMID 30292888›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2019

The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications.

Vadim Osadchiy, Clair R Martin, Emeran A Mayer

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04315714 (Impact of a Yoga Intervention on Chronic Abdominal Pain, and Associations With the Metagenome and Metabolome in Participants With IBS), which is not on this map. Cited by 298 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
298citing papers in PubMed, 9 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04315714 nacompletednot on this mapstarted 2021, after this paper: background citation

Impact of a Yoga Intervention on Chronic Abdominal Pain, and Associations With the Metagenome and Metabolome in Participants With IBS

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2021 to 2021Enrolled17ConditionsIrritable Bowel Syndrome, Abdominal PainArmsYoga Program
3 · Its place in the literature

Who cites it

298 citing papers in PubMed, 9 syntheses or guidelines pooled it, 515 citations in OpenAlex.

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  17. Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.European archives of psychiatry and clinical neuroscience · 2026
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238 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vadim OsadchiyG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California.
Clair R MartinG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California.
Emeran A MayerG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California. Electronic address: emayer@ucla.edu.
University of California, Los Angeles · US

Funding

Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Neurobiological mechanisms underlying effectiveness of CBT in IBS patientsR01DK096606 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LACKNER, JEFFREY M, MAYER, EMERAN A · 2012 to 2015
$1.9M
NIDDK NIH HHS P50 DK064539NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R01 DK096606
6 · The paper itself

Abstract

BACKGROUND &

aimsBased largely on results from preclinical studies, the concept of a brain gut microbiome axis has been established, mediating bidirectional communication between the gut, its microbiome, and the nervous system. Limited data obtained in human beings suggest that alterations in these interactions may play a role in several brain gut disorders.

methodsWe reviewed the preclinical and clinical literature related to the topic of brain gut microbiome interactions.

resultsWell-characterized bidirectional communication channels, involving neural, endocrine, and inflammatory mechanisms, exist between the gut and the brain. Communication through these channels may be modulated by variations in the permeability of the intestinal wall and the blood-brain barrier. Brain gut microbiome interactions are programmed during the first 3 years of life, including the prenatal period, but can be modulated by diet, medications, and stress throughout life. Based on correlational studies, alterations in these interactions have been implicated in the regulation of food intake, obesity, and in irritable bowel syndrome, even though causality remains to be established.

conclusionsTargets within the brain gut microbiome axis have the potential to become targets for novel drug development for brain gut disorders.

Indexed as

Gastrointestinal MicrobiomeHost Microbial InteractionsMicrobiotaBiological FactorsBrainGastrointestinal TractHumansBiological FactorsDietEarly Life InfluencesIrritable Bowel Syndrome

Identifiers

PMID30292888
PMCPMC6999848
OpenAlexW2895386130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.