ArticleJournal of neuroscience methods2019
A quantitative method for evaluating cortical responses to electrical stimulation.
Article in Journal of neuroscience methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex.PLoS computational biology · 2026Article
- Optimization of cortico-cortical spectral response analysis parameters for seizure onset zone localization.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Multimodal evidence for hippocampal engagement and modulation by functional connectivity-guided parietal TMS.Nature communications · 2026Article
- Advanced Brain-on-a-Chip for Wetware Computing: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG.bioRxiv : the preprint server for biology · 2024Article
- Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Intraoperative Neurophysiological Monitoring in Neurosurgery.Journal of clinical medicine · 2024Review
- High-Frequency Local Field Potential Oscillations for Pigeons in Effective Turning.Animals : an open access journal from MDPI · 2024Article
- ER-detect: a pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.bioRxiv : the preprint server for biology · 2024Article
- Single-pulse electrical stimulation artifact removal using the novel matching pursuit-based artifact reconstruction and removal method (MPARRM).Journal of neural engineering · 2023Article
- TMS provokes target-dependent intracranial rhythms across human cortical and subcortical sites.bioRxiv : the preprint server for biology · 2023Article
- Dynamic Visualization of Gyral and Sulcal Stereoelectroencephalographic Contacts in Humans.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- Electrical Stimulation of Temporal and Limbic Circuitry Produces Distinct Responses in Human Ventral Temporal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.PLoS computational biology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundElectrical stimulation of the cortex using subdurally implanted electrodes can causally reveal structural connectivity by eliciting cortico-cortical evoked potentials (CCEPs). While many studies have demonstrated the potential value of CCEPs, the methods to evaluate them were often relatively subjective, did not consider potential artifacts, and did not lend themselves to systematic scientific investigations. NEW
methodWe developed an automated and quantitative method called SIGNI (Stimulation-Induced Gamma-based Network Identification) to evaluate cortical population-level responses to electrical stimulation that minimizes the impact of electrical artifacts. We applied SIGNI to electrocorticographic (ECoG) data from eight human subjects who were implanted with a total of 978 subdural electrodes. Across the eight subjects, we delivered 92 trains of approximately 200 discrete electrical stimuli each (amplitude 4-15 mA) to a total of 64 electrode pairs.
resultsWe verified SIGNI's efficacy by demonstrating a relationship between the magnitude of evoked cortical activity and stimulation amplitude, as well as between the latency of evoked cortical activity and the distance from the stimulated locations.
conclusionsSIGNI reveals the timing and amplitude of cortical responses to electrical stimulation as well as the structural connectivity supporting these responses. With these properties, it enables exploration of new and important questions about the neurophysiology of cortical communication and may also be useful for pre-surgical planning.
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