ArticleNeuroImage2019
On the scaling behavior of water diffusion in human brain white matter.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology.NeuroImage · 2021Pooled it
- Comparative Systematic Analysis of Gray Matter Biophysical Models on a Public Dataset.Magnetic resonance in medicine · 2026Article
- The Association of Apparent Myelin Water Fraction With Diffusional Kurtosis and Biophysical Modeling Parameters.NMR in biomedicine · 2026Article
- Effects of perfusion fixation on whole-brain structural connectivity in marmoset: a diffusion MRI analysis.Radiological physics and technology · 2026Article
- Axon Diameter Mapping in the Living Human Brain with Ultra-High-Gradient Diffusion MRI at 500 mT/m Gradient Strength.Human brain mapping · 2026Article
- Validating the standard model of diffusion MRI in white matter with numerical substrates.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Advanced microstructure imaging at high b-values and high resolution combining ultra-high performance gradient diffusion imaging and model-based deep learning demonstrated using 3D multi-slab acquisition.Magnetic resonance in medicine · 2026Article
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Scattering approach to diffusion quantifies axonal damage in brain injury.Nature communications · 2025Article
- Oscillating gradient spin echo diffusion time effects implicate variations in neurite beading for the heterogeneous reduced diffusion in human acute ischemic stroke lesions.Magnetic resonance in medicine · 2025Article
- Article
- Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging.Nature protocols · 2025Review
- In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects.NeuroImage · 2025Article
- Alpha_Mesh_Swc: automatic and robust surface mesh generation from the skeleton description of brain cells.Briefings in bioinformatics · 2025Article
- Quasi-Diffusion Imaging: Application to Ultra-High b-Value and Time-Dependent Diffusion Images of Brain Tissue.NMR in biomedicine · 2025Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- Investigating microstructural changes between in vivo and perfused ex vivo marmoset brains using oscillating gradient and b-tensor encoded diffusion MRI at 9.4 T.Magnetic resonance in medicine · 2025Article
- MRI-scale histology validates spatial sensitivity of in-vivo MRI-based axon radius estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characterization of neurite and soma organization in the brain and spinal cord with diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Development of therapies for neurological disorders depends on our ability to non-invasively diagnose and monitor the progression of underlying pathologies at the cellular level. Physics and physiology limit the resolution of human MRI to be orders of magnitude coarser than cell dimensions. Here we identify and quantify the MRI signal coming from within micrometer-thin axons in human white matter tracts in vivo, by utilizing the sensitivity of diffusion MRI to Brownian motion of water molecules restricted by cell walls. We study a specific power-law scaling of the diffusion MRI signal with the diffusion weighting, predicted for water confined to narrow axons, and quantify axonal water fraction and orientation dispersion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.