Evidence map›Paper›PMID 30292719›Full record

ArticleNeuroscience letters2019

A preliminary examination of the relation between neural sensitivity to reward and history of alcohol use disorder among adults with internalizing psychopathologies.

Hanna Hixson, Katie L Burkhouse, Stephanie M Gorka, Heide Klumpp

Abstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hanna HixsonUniversity of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, United States.
Katie L BurkhouseUniversity of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, United States. Electronic address: kburkho@uic.edu.
Stephanie M GorkaUniversity of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, United States.
Heide KlumppUniversity of Illinois-Chicago, Department of Psychiatry, 1747 West Roosevelt Road, Chicago, IL 60608, United States; University of Illinois-Chicago, Departments of Psychology and Anatomy and Cell, Biology, and the Graduate Program in Neuroscience, 808 S. Wood Street, Chicago, IL 60612, United States.

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029879 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAZZONE, THEODORE · 2009 to 2011
$11.0M
Brain-Behavior Markers of Emotion in Depressed Mothers and Their DaughtersK23MH113793 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURKHOUSE, KATIE L · 2017 to 2021
$1.0M
Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety DisorderK23MH093679 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KLUMPP, HEIDE · 2012 to 2016
$948k
Brain-Behavior Reactivity to Threat and Alcohol Abuse Risk in Young AdultsK23AA025111 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GORKA, STEPHANIE · 2017 to 2020
$764k
NCATS NIH HHS UL1 TR002003NCRR NIH HHS UL1 RR029879NIAAA NIH HHS K23 AA025111NIMH NIH HHS K23 MH093679NIMH NIH HHS K23 MH113793
6 · The paper itself

Abstract

Decreased reward responsiveness, as demonstrated utilizing the event-related potential (ERP) component the reward positivity (RewP), is an established correlate of internalizing psychopathologies (IPs), such as depressive and anxiety disorders. Although IPs are highly comorbid with alcohol use disorders (AUDs) and despite evidence that AUDs are also characterized by aberrant reward processing styles, no studies have examined how AUD history impacts the RewP among adults with IPs. The current preliminary study sought to examine this question in a sample of 65 adults with 1) current IPs (i.e., depression, social anxiety, and/or generalized anxiety, 2) current IPs with a history of an AUD (IP + Past AUD), and 3) no history of a DSM-IV disorder. Participants completed a guessing reward task while electroencephalogram (EEG) was recorded. Results indicated that participants in the IP group exhibited a more attenuated RewP relative to IP + Past AUD and healthy control individuals. Findings from this study highlight the importance of examining diagnostic subgroups among adults with anxiety and depressive disorders, and suggest that a history of AUD may enhance reward reactivity at the neural level in individuals with IPs.

Indexed as

RewardAlcoholismAnxietyCase-Control StudiesDepressionElectroencephalographyEvoked PotentialsFemaleHumansMaleYoung AdultAlcoholismAnxietyDepressionEEGERPInternalizing disordersReward positivity

Identifiers

PMID30292719
PMCPMC6320293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.