ArticleMolecular plant2018
Medicago AP2-Domain Transcription Factor WRI5a Is a Master Regulator of Lipid Biosynthesis and Transfer during Mycorrhizal Symbiosis.
Article in Molecular plant, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 151 citations in OpenAlex.
- Responses of arbuscular mycorrhizal wheat to salinity: from symbiotic signaling to stress adaptation.Plant signaling & behavior · 2026Review
- OsIDD7 integrates signaling networks for arbuscular mycorrhizal symbiosis.Nature communications · 2026Article
- Evaluating Causal Claims in Plant Developmental Metabolism: A When-Where-How Framework.Plants (Basel, Switzerland) · 2026Review
- Review
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- PfWRI1-10 transcription factor mediates lipid synthesis in Perilla frutescens through regulating PfBCCP1 gene transcription.BMC plant biology · 2026Article
- Functional diversification of WRINKLED3 integrates fatty acid metabolism with insecticidal acylsugar production in Solanaceae species.Nature communications · 2026Article
- Contribution of orchids to the carbon budget of fungi in germinating seeds of Gymnadenia conopsea.Science China. Life sciences · 2026Article
- Beyond phosphate uptake: PT4/PT11 as key functional components linking phosphate acquisition, nutrient exchange, and arbuscule maintenance in arbuscular mycorrhizal symbiosis.Frontiers in plant science · 2026Review
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- Comparative transcriptomics reveals differential carbohydrate and lipid metabolism in roots and nodules of Rhizobia-Inoculated alfalfa (Medicago sativa L.).BMC plant biology · 2025Article
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2025Article
- ABA promotes fatty acid biosynthesis and transport to boost arbuscular mycorrhizal symbiosis in apple roots.Plant communications · 2025Article
- The GRAS protein RAM1 interacts with WRI transcription factors to regulate plant genes required for arbuscule development and function.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unravelling the Molecular Dialogue of Beneficial Microbe-Plant Interactions.Plant, cell & environment · 2025Review
- Genome-Wide Identification, Expression, and Protein Interaction ofInternational journal of molecular sciences · 2025Article
- Fatty Acid ABCG TransporterPlants (Basel, Switzerland) · 2025Article
- Sugars, Lipids and More: New Insights Into Plant Carbon Sources During Plant-Microbe Interactions.Plant, cell & environment · 2025Review
- Mechanisms of cooperation in the plants-arbuscular mycorrhizal fungi-bacteria continuum.The ISME journal · 2025Review
- Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for experimental validation of the mosaic translation hypothesis.Computational and structural biotechnology journal · 2025Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most land plants have evolved a mutualistic symbiosis with arbuscular mycorrhiza (AM) fungi that improve nutrient acquisition from the soil. In return, up to 20% of host plant photosynthate is transferred to the mycorrhizal fungus in the form of lipids and sugar. Nutrient exchange must be regulated by both partners in order to maintain a reliable symbiotic relationship. However, the mechanisms underlying the regulation of lipid transfer from the plant to the AM fungus remain elusive. Here, we show that the Medicago truncatula AP2/EREBP transcription factor WRI5a, and likely its two homologs WRI5b/Erf1 and WRI5c, are master regulators of AM symbiosis controlling lipid transfer and periarbuscular membrane formation. We found that WRI5a binds AW-box cis-regulatory elements in the promoters of M. truncatula STR, which encodes a periarbuscular membrane-localized ABC transporter required for lipid transfer from the plant to the AM fungus, and MtPT4, which encodes a phosphate transporter required for phosphate transfer from the AM fungus to the plant. The hairy roots of the M. truncatula wri5a mutant and RNAi composite plants displayed impaired arbuscule formation, whereas overexpression of WRI5a resulted in enhanced expression of STR and MtPT4, suggesting that WRI5a regulates bidirectional symbiotic nutrient exchange. Moreover, we found that WRI5a and RAM1 (Required for Arbuscular Mycorrhization symbiosis 1), which encodes a GRAS-domain transcription factor, regulate each other at the transcriptional level, forming a positive feedback loop for regulating AM symbiosis. Collectively, our data suggest a role for WRI5a in controlling bidirectional nutrient exchange and periarbuscular membrane formation via the regulation of genes involved in the biosynthesis of fatty acids and phosphate uptake in arbuscule-containing cells.
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