ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2018
Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.
Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Efficacy and safety of single-anastomosis gastric bypass variants versus sleeve gastrectomy or Roux-en-Y gastric bypass: a systematic review and meta-analysis.Updates in surgery · 2026Pooled it
- Changes in fasting bile acid profiles after Roux-en-Y gastric bypass and sleeve gastrectomy.Medicine · 2021Pooled it
- Weight Loss and Vomiting 1 Year After Banded Versus Non-banded One Anastomosis Gastric Bypass: a Prospective Randomized Trial.Obesity surgery · 2020Trial
- Towards a better mouse model of vertical sleeve gastrectomy.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025Article
- Laparoscopic Single Anastomosis Sleeve Ileal Bypass Versus Laparoscopic Roux-en-Y Gastric Bypass as Single Stage Procedure for Management of Patients with Class V Obesity (BMI ≥ 60 kg/mObesity surgery · 2025Article
- The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.Cell metabolism · 2022Article
- Bariatric Surgery in NAFLD.Digestive diseases and sciences · 2022Review
- Gut HIF2α signaling is increased after VSG, and gut activation of HIF2α decreases weight, improves glucose, and increases GLP-1 secretion.Cell reports · 2022Article
- The many faces of diabetes. Is there a need for re-classification? A narrative review.BMC endocrine disorders · 2022Review
- Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice.Nature communications · 2021Article
- Changes in Body Composition and Biochemical Parameters Following Laparoscopic One Anastomosis Gastric Bypass: 1-Year Follow-Up.Obesity surgery · 2021Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
- Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?Frontiers in endocrinology · 2020Review
- Changes in serum albumin and liver enzymes following three different types of bariatric surgery: six-month follow-up. A retrospective cohort study.Sao Paulo medical journal = Revista paulista de medicinaArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOne-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.
objectivesTo examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model.
settingAcademic research laboratory, United States.
methodsSurgeries were performed in diet-induced obese Long-Evans rats, and metabolic outcomes were monitored before and for 15 weeks after surgery.
resultsAll bariatric procedures induced weight loss compared with sham that lasted throughout the course of the study. The highest percent fat loss occurred after OAGB and RYGB. All bariatric procedures had improved glucose dynamics associated with an increase in insulin (notably OAGB and SADS) and/or glucagon-like protein-1 secretion. Circulating cholesterol was reduced in OAGB, SG, and RYGB. OAGB and SG additionally decreased circulating triglycerides. Liver triglycerides were most profoundly reduced after OAGB and RYGB. Circulating iron levels were decreased in all surgical groups, associated with a decreased hematocrit value and increased reticulocyte count. The fecal microbiome communities of OAGB, SADS, and RYGB were significantly altered; however, SG exhibited no change in microbiome diversity or composition.
conclusionsThese data support the use of the rat for modeling bariatric surgical procedures and highlight the ability of the OAGB to meet or exceed the metabolic improvements of RYGB. These data point to the likelihood that each surgery accomplishes metabolic improvements through both overlapping and distinct mechanisms and warrants further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.