Evidence map›Paper›PMID 30292631›Full record

ArticleClinica chimica acta; international journal of clinical chemistry2018

Quality specifications and their daily application to evaluate the accuracy of reference measurements for serum concentrations of 25-hydroxyvitamin D

Ekaterina M Mineva, Maya R Sternberg, Christine M Pfeiffer, Shahzad S Momin, Khin L Maw, Rosemary L Schleicher

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Article in Clinica chimica acta; international journal of clinical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ekaterina M MinevaDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.
Maya R SternbergDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.
Christine M PfeifferDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.
Shahzad S MominDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.
Khin L MawDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States.
Rosemary L SchleicherDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Electronic address: zwa5@cdc.gov.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundReference measurement procedures (RMP) have rigorous accuracy specifications. For total 25-hydroxyvitamin D, 25(OH)D, bias ≤1.7% and CV ≤5% are recommended. These quality specifications are impractical for minor analytes, such as 25(OH)D

methodsTo assess accuracy, we used zeta-scores. Daily, 5-10 specimens (duplicate) and 3 reference materials (singleton or duplicate) were measured for 25(OH)D

resultsAcross 7 campaigns, unacceptable daily zeta-scores required repeating 2 runs for 25(OH)D

conclusionsUsing zeta-scores and experimentally derived imprecision, we developed a straightforward approach to assess the acceptability of individual 25(OH)D reference measurements, providing also much-needed practical accuracy specifications for 25(OH)D

Indexed as

25-Hydroxyvitamin D 2CalcifediolChromatography, LiquidHumansReference StandardsTandem Mass Spectrometry25-Hydroxyvitamin D 2Calcifediol25(OH)D(2)25(OH)D(3)Quality performance specificationsReference measurement procedureSerumVitamin D

Identifiers

PMID30292631
PMCPMC7982963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.