Evidence map›Paper›PMID 30292347›Full record

ArticleTrends in cancer2018

We Are All Connected: Modeling the Tumor-Immune Ecosystem.

Jonathan D Schoenfeld

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Gaming the cancer-immunity cycle by synchronizing the dose schedules.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Jonathan D SchoenfeldDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. Electronic address: jonathan_schoenfeld@dfci.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor-reactive immune cells link tumor responses at anatomically distant locations, yet this interconnectedness is poorly understood on a macro level. Can we use mathematical models to better understand these complex relationships? Recent work provides a framework to evaluate the effects that T cells generated at one site may have on metastases elsewhere in the body and suggests that in the era of immunotherapy the concept of 'local' therapy needs to be refined.

Indexed as

NeoplasmsCombined Modality TherapyEcosystemHumansImmunotherapyT-Lymphocytesabscopal effectimmunotherapymathematical modelingradiotherapysurgeryT cell trafficking

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.